mostFrequent#K=3#Top=0.3pct#Filter=[]#[iMM904_peroxisome,glucose_aerobic,NONE,criticals_glucose_aerobic,BASE,SPEA2GK_K20,PFBA,BPCY]

---

• SER3^YER081W SER33^YIL074C ZWF1^YNL241C
• succinate
• SDH2^YLL041C [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• KGD2^YDR148C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• KGD1^YIL125W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH2^YLL041C CAR2^YLR438W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• KGD2^YDR148C SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4511, FVA~min~R_EX_succ_e_ (pFBA)=0,7776]
• malate
• MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4598, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4118, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,6207, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ALT2^YDR111C AGX1^YFL030W TDH3^YGR192C TDH1^YJL052W TDH2^YJR009C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,6154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• FUM1^YPL262W [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• PGI1^YBR196C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4441, FVA~min~R_EX_fum_e_ (pFBA)=0,7660]
• AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• KGD2^YDR148C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• AAT1^YKL106W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• UGA2^YBR006W IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4795, FVA~min~R_EX_fum_e_ (pFBA)=0,8269]
• PGI1^YBR196C MAE1^YKL029C AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_fum_e_ (pFBA)=0,7666]
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• KGD2^YDR148C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• BAT1^YHR208W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]

---

• SER3^YER081W SER33^YIL074C RPE1^YJL121C
• succinate
• SDH2^YLL041C [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,4476, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4476, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4476, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4476, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4475, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• SDH4^YDR178W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4476, FVA~min~R_EX_succ_e_ (pFBA)=0,7715]
• malate
• TPI1^YDR050C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• FUM1^YPL262W [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4328, FVA~min~R_EX_fum_e_ (pFBA)=0,7465]
• LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4323, FVA~min~R_EX_fum_e_ (pFBA)=0,7456]
• GDH3^YAL062W GDH1^YOR375C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4418, FVA~min~R_EX_fum_e_ (pFBA)=0,7621]
• KGD2^YDR148C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• BAT1^YHR208W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• MAE1^YKL029C PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• SER3^YER081W SER33^YIL074C MET17^YLR303W
• succinate
• TPI1^YDR050C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• TPI1^YDR050C SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W RPE1^YJL121C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W RPE1^YJL121C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W RPE1^YJL121C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• malate
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PGI1^YBR196C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,3094, FVA~min~R_EX_fum_e_ (pFBA)=0,5336]
• RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4328, FVA~min~R_EX_fum_e_ (pFBA)=0,7465]
• ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• PGI1^YBR196C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3168, FVA~min~R_EX_fum_e_ (pFBA)=0,5464]
• GDH2^YDL215C MTD1^YKR080W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3570, FVA~min~R_EX_fum_e_ (pFBA)=0,6157]
• TPI1^YDR050C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• GLY1^YEL046C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• AAT1^YKL106W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• GDH2^YDL215C GRE3^YHR104W MTD1^YKR080W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4378, FVA~min~R_EX_fum_e_ (pFBA)=0,7551]
• ARO3^YDR035W GLY1^YEL046C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• TPI1^YDR050C SHM2^YLR058C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GDH3^YAL062W SOR1^YJR159W MTD1^YKR080W GDH1^YOR375C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4587, FVA~min~R_EX_fum_e_ (pFBA)=0,7910]
• PGI1^YBR196C ARO3^YDR035W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C ARO3^YDR035W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C LSC2^YGR244C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C BAT1^YHR208W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C MAE1^YKL029C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]

---

• PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W
• succinate
• PGI1^YBR196C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• ACH1^YBL015W PGI1^YBR196C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W FBA1^YKL060C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• PGI1^YBR196C SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PGI1^YBR196C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4429, FVA~min~R_EX_succ_e_ (pFBA)=0,7640]
• malate
• RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C SOR1^YJR159W MAE1^YKL029C MDH1^YKL085W MTD1^YKR080W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• SER3^YER081W SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W SER33^YIL074C MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]

---

• SER3^YER081W SER33^YIL074C MET2^YNL277W
• succinate
• TPI1^YDR050C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• TPI1^YDR050C SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• TPI1^YDR050C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• malate
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• GLY1^YEL046C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• LSC2^YGR244C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• MAE1^YKL029C ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• PGI1^YBR196C KGD2^YDR148C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• GLY1^YEL046C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GLY1^YEL046C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER33^YIL074C ZWF1^YNL241C MET2^YNL277W
• succinate
• SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH2^YLL041C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• malate
• SER3^YER081W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER3^YER081W ZWF1^YNL241C MET2^YNL277W
• succinate
• SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH2^YLL041C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• malate
• IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER3^YER081W SER33^YIL074C CAR2^YLR438W
• succinate
• SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH3^YKL141W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH1^YKL148C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH2^YLL041C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH2^YLL041C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W YJL045W^YJL045W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SDH3^YKL141W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• malate
• AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PGI1^YBR196C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• GLY1^YEL046C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• PGI1^YBR196C KGD2^YDR148C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C LPD1^YFL018C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• PGI1^YBR196C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• ARO3^YDR035W GLY1^YEL046C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• TPI1^YDR050C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• KGD2^YDR148C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• MAE1^YKL029C ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PGI1^YBR196C KGD2^YDR148C MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C KGD1^YIL125W MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C MAE1^YKL029C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• IPP1^YBR011C TPI1^YDR050C SHM2^YLR058C MET17^YLR303W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• PGI1^YBR196C ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER33^YIL074C MET17^YLR303W ZWF1^YNL241C
• succinate
• SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER3^YER081W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• malate
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• SER3^YER081W MET17^YLR303W ZWF1^YNL241C
• succinate
• SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SER33^YIL074C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4526, FVA~min~R_EX_succ_e_ (pFBA)=0,7802]
• malate
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER33^YIL074C AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• THI3^YDL080C ARO10^YDR380W SER33^YIL074C AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W ARO3^YDR035W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• PDC6^YGR087C PDC1^YLR044C ZWF1^YNL241C
• succinate
• SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• PGI1^YBR196C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4429, FVA~min~R_EX_succ_e_ (pFBA)=0,7640]
• SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• malate
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• SER3^YER081W SER33^YIL074C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W SER33^YIL074C PDC5^YLR134W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]

---

• PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C
• succinate
• PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• PGI1^YBR196C PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4429, FVA~min~R_EX_succ_e_ (pFBA)=0,7640]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• PDC6^YGR087C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• malate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC6^YGR087C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]

---

• PDC6^YGR087C PDC5^YLR134W ZWF1^YNL241C
• succinate
• SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• PGI1^YBR196C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4429, FVA~min~R_EX_succ_e_ (pFBA)=0,7640]
• SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_succ_e_ (pFBA)=0,7534]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• ACH1^YBL015W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• malate
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• SER3^YER081W SER33^YIL074C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W SER33^YIL074C PDC1^YLR044C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]

---

• SER3^YER081W SER33^YIL074C MAE1^YKL029C
• malate
• MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0200, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0767, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4598, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MDH1^YKL085W MET17^YLR303W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0751, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W MDH1^YKL085W MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0179, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4118, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MDH1^YKL085W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,6207, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W ARO3^YDR035W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0655, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C BAT1^YHR208W RPE1^YJL121C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• PGI1^YBR196C KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• ARO3^YDR035W GLY1^YEL046C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• KGD2^YDR148C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• KGD2^YDR148C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• GLY1^YEL046C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• GLY1^YEL046C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• GLY1^YEL046C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD1^YIL125W RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• PGI1^YBR196C KGD2^YDR148C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C KGD2^YDR148C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C KGD2^YDR148C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C LPD1^YFL018C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• PGI1^YBR196C LPD1^YFL018C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• PGI1^YBR196C LSC2^YGR244C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C BAT1^YHR208W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C KGD1^YIL125W PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]

---

• SER3^YER081W SER33^YIL074C FUM1^YPL262W
• succinate
• SDH2^YLL041C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SDH3^YKL141W ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SDH1^YKL148C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SDH2^YLL041C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SHH4^YLR164W ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH3^YKL141W SHH3^YMR118C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH1^YKL148C SDH2^YLL041C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH2^YLL041C SHH4^YLR164W ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH2^YLL041C SHH3^YMR118C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W YJL045W^YJL045W SHH4^YLR164W ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SDH3^YKL141W SHH4^YLR164W ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• fumarate
• PGI1^YBR196C [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• RPE1^YJL121C [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• ZWF1^YNL241C [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• PGI1^YBR196C MET17^YLR303W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,3094, FVA~min~R_EX_fum_e_ (pFBA)=0,5336]
• PGI1^YBR196C CAR2^YLR438W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4441, FVA~min~R_EX_fum_e_ (pFBA)=0,7660]
• GDH2^YDL215C MTD1^YKR080W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,3561, FVA~min~R_EX_fum_e_ (pFBA)=0,6141]
• GLY1^YEL046C MAE1^YKL029C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• RPE1^YJL121C MET17^YLR303W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4328, FVA~min~R_EX_fum_e_ (pFBA)=0,7465]
• RPE1^YJL121C LEU4^YNL104C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4323, FVA~min~R_EX_fum_e_ (pFBA)=0,7456]
• AAT1^YKL106W ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• MET17^YLR303W ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• ZWF1^YNL241C MET2^YNL277W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• CDC19^YAL038W FBP1^YLR377C PYK2^YOR347C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1428, FVA~min~R_EX_fum_e_ (pFBA)=0,2463]
• GDH3^YAL062W RPE1^YJL121C GDH1^YOR375C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4418, FVA~min~R_EX_fum_e_ (pFBA)=0,7621]
• PGI1^YBR196C KGD2^YDR148C MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C KGD1^YIL125W MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3168, FVA~min~R_EX_fum_e_ (pFBA)=0,5464]
• GDH2^YDL215C MTD1^YKR080W MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3570, FVA~min~R_EX_fum_e_ (pFBA)=0,6157]
• ARO3^YDR035W GLY1^YEL046C MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]

---

• SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W
• succinate
• SER3^YER081W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH3^YKL141W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH2^YLL041C SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• fumarate
• SER3^YER081W [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• PGI1^YBR196C SER3^YER081W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4441, FVA~min~R_EX_fum_e_ (pFBA)=0,7660]
• SER3^YER081W AAT1^YKL106W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• SER3^YER081W MET17^YLR303W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W MET2^YNL277W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• SER3^YER081W AAT1^YKL106W MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• UGA2^YBR006W SER3^YER081W IDP2^YLR174W ALD6^YPL061W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4795, FVA~min~R_EX_fum_e_ (pFBA)=0,8269]
• PGI1^YBR196C SER3^YER081W MAE1^YKL029C AAT1^YKL106W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_fum_e_ (pFBA)=0,7666]
• ARO3^YDR035W KGD2^YDR148C SER3^YER081W MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER3^YER081W KGD1^YIL125W MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C CAR2^YLR438W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C CAR2^YLR438W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C LSC1^YOR142W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]

---

• SER3^YER081W ZWF1^YNL241C FUM1^YPL262W
• succinate
• SER33^YIL074C SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH3^YKL141W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH2^YLL041C SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• fumarate
• SER33^YIL074C [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• PGI1^YBR196C SER33^YIL074C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4441, FVA~min~R_EX_fum_e_ (pFBA)=0,7660]
• SER33^YIL074C AAT1^YKL106W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• SER33^YIL074C MET17^YLR303W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER33^YIL074C MET2^YNL277W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• SER33^YIL074C AAT1^YKL106W MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• UGA2^YBR006W SER33^YIL074C IDP2^YLR174W ALD6^YPL061W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4795, FVA~min~R_EX_fum_e_ (pFBA)=0,8269]
• PGI1^YBR196C SER33^YIL074C MAE1^YKL029C AAT1^YKL106W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_fum_e_ (pFBA)=0,7666]
• ARO3^YDR035W KGD2^YDR148C SER33^YIL074C MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C LSC1^YOR142W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]

---

• SER33^YIL074C CAR2^YLR438W ZWF1^YNL241C
• succinate
• SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER3^YER081W SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER3^YER081W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• malate
• SER3^YER081W AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• SER3^YER081W CAR2^YLR438W ZWF1^YNL241C
• succinate
• SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4512, FVA~min~R_EX_succ_e_ (pFBA)=0,7778]
• malate
• AGX1^YFL030W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C RPE1^YJL121C PDC1^YLR044C
• succinate
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• malate
• MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W SER33^YIL074C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• IDP1^YDL066W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• RPE1^YJL121C PDC1^YLR044C PDC5^YLR134W
• succinate
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• malate
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• IDP1^YDL066W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C SHM2^YLR058C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• PDC6^YGR087C RPE1^YJL121C PDC5^YLR134W
• succinate
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• malate
• MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W SER33^YIL074C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• IDP1^YDL066W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C
• succinate
• SDH2^YLL041C [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• IPP1^YBR011C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2495, FVA~min~R_EX_succ_e_ (pFBA)=0,4297]
• SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• AAT1^YKL106W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2450, FVA~min~R_EX_succ_e_ (pFBA)=0,4219]
• IPP1^YBR011C SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2495, FVA~min~R_EX_succ_e_ (pFBA)=0,4297]
• IPP1^YBR011C SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2495, FVA~min~R_EX_succ_e_ (pFBA)=0,4297]
• IPP1^YBR011C SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2495, FVA~min~R_EX_succ_e_ (pFBA)=0,4297]
• IPP1^YBR011C SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2495, FVA~min~R_EX_succ_e_ (pFBA)=0,4297]
• IPP1^YBR011C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2495, FVA~min~R_EX_succ_e_ (pFBA)=0,4297]
• malate
• MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2559, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDA1^YER178W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• FUM1^YPL262W [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4209]
• KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ALT2^YDR111C AGX1^YFL030W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2447, FVA~min~R_EX_fum_e_ (pFBA)=0,4219]
• ALT2^YDR111C AGX1^YFL030W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2447, FVA~min~R_EX_fum_e_ (pFBA)=0,4219]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• SER3^YER081W LPD1^YFL018C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]

---

• SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C
• malate
• SER3^YER081W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4598, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4118, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W IRC7^YFR055W MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W SER3^YER081W MDH1^YKL085W MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,6207, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MDH1^YKL085W AAT2^YLR027C MET17^YLR303W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ALT2^YDR111C SER3^YER081W AGX1^YFL030W TDH3^YGR192C TDH1^YJL052W TDH2^YJR009C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,6154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• SER3^YER081W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• PGI1^YBR196C SER3^YER081W AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_fum_e_ (pFBA)=0,7666]
• ARO3^YDR035W KGD2^YDR148C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER3^YER081W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• KGD2^YDR148C SER3^YER081W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W BAT1^YHR208W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W KGD1^YIL125W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W MET2^YNL277W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• ARO3^YDR035W KGD2^YDR148C SER3^YER081W BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER3^YER081W BAT1^YHR208W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• PRO1^YDR300C SER3^YER081W LSC2^YGR244C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PRO1^YDR300C SER3^YER081W BAT1^YHR208W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]

---

• SER3^YER081W MAE1^YKL029C ZWF1^YNL241C
• malate
• SER33^YIL074C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4598, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W SER33^YIL074C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4118, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W SER33^YIL074C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W SER33^YIL074C MDH1^YKL085W MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,6207, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ALT2^YDR111C AGX1^YFL030W TDH3^YGR192C SER33^YIL074C TDH1^YJL052W TDH2^YJR009C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,6154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4349, FVA~min~R_EX_fum_e_ (pFBA)=0,7502]
• PGI1^YBR196C SER33^YIL074C AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_fum_e_ (pFBA)=0,7666]
• ARO3^YDR035W KGD2^YDR148C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• KGD2^YDR148C SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C SER33^YIL074C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• BAT1^YHR208W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C KGD1^YIL125W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C MET2^YNL277W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• ARO3^YDR035W KGD2^YDR148C BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W BAT1^YHR208W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• PRO1^YDR300C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PRO1^YDR300C BAT1^YHR208W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]

---

• SER3^YER081W BAT1^YHR208W SER33^YIL074C
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• PGI1^YBR196C KGD2^YDR148C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• KGD2^YDR148C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• GLY1^YEL046C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• LSC2^YGR244C RPE1^YJL121C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• LSC2^YGR244C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• RPE1^YJL121C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• MAE1^YKL029C ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• GDH3^YAL062W MTD1^YKR080W IDH1^YNL037C GDH1^YOR375C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0686, FVA~min~R_EX_fum_e_ (pFBA)=0,1181]
• GDH3^YAL062W MTD1^YKR080W IDH2^YOR136W GDH1^YOR375C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0686, FVA~min~R_EX_fum_e_ (pFBA)=0,1181]
• PGI1^YBR196C KGD2^YDR148C PRO1^YDR300C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C PRO1^YDR300C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C MAE1^YKL029C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• PGI1^YBR196C SER3^YER081W SER33^YIL074C
• succinate
• GDH2^YDL215C MTD1^YKR080W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SDH3^YKL141W MTD1^YKR080W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SDH1^YKL148C MTD1^YKR080W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W MTD1^YKR080W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W MTD1^YKR080W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C YJL045W^YJL045W SDH1^YKL148C MTD1^YKR080W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C YJL045W^YJL045W MTD1^YKR080W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH3^YKL141W SDH1^YKL148C MTD1^YKR080W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH3^YKL141W MTD1^YKR080W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH3^YKL141W MTD1^YKR080W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH1^YKL148C MTD1^YKR080W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C MTD1^YKR080W SDH2^YLL041C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C MTD1^YKR080W SDH2^YLL041C SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• GDH2^YDL215C SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W MTD1^YKR080W MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C MTD1^YKR080W MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W YJL045W^YJL045W MTD1^YKR080W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W YJL045W^YJL045W MTD1^YKR080W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C MTD1^YKR080W MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SDH3^YKL141W MTD1^YKR080W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• fumarate
• FUM1^YPL262W [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,3094, FVA~min~R_EX_fum_e_ (pFBA)=0,5336]
• CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4441, FVA~min~R_EX_fum_e_ (pFBA)=0,7660]
• KGD2^YDR148C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3168, FVA~min~R_EX_fum_e_ (pFBA)=0,5464]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• KGD2^YDR148C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• LPD1^YFL018C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• LPD1^YFL018C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• MAE1^YKL029C AAT1^YKL106W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_fum_e_ (pFBA)=0,7666]
• MAE1^YKL029C PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• ARO3^YDR035W LSC2^YGR244C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• ARO3^YDR035W MAE1^YKL029C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]

---

• SER33^YIL074C RPE1^YJL121C MET17^YLR303W
• succinate
• SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER3^YER081W SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER3^YER081W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• fumarate
• SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4328, FVA~min~R_EX_fum_e_ (pFBA)=0,7465]

---

• SER3^YER081W RPE1^YJL121C MET17^YLR303W
• succinate
• SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4491, FVA~min~R_EX_succ_e_ (pFBA)=0,7741]
• fumarate
• SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4328, FVA~min~R_EX_fum_e_ (pFBA)=0,7465]

---

• SER3^YER081W SER33^YIL074C PDC1^YLR044C
• succinate
• PDC6^YGR087C RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC6^YGR087C RPE1^YJL121C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• PDC6^YGR087C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• PDC6^YGR087C PDC5^YLR134W MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC6^YGR087C SER33^YIL074C
• succinate
• RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W RPE1^YJL121C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• RPE1^YJL121C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• PDC1^YLR044C PDC5^YLR134W MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W SER33^YIL074C PDC5^YLR134W
• succinate
• PDC6^YGR087C RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC6^YGR087C RPE1^YJL121C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• PDC6^YGR087C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• PDC6^YGR087C PDC1^YLR044C MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• PDC6^YGR087C SER33^YIL074C PDC1^YLR044C
• succinate
• SER3^YER081W RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER3^YER081W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER3^YER081W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER3^YER081W RPE1^YJL121C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W RPE1^YJL121C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W RPE1^YJL121C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W RPE1^YJL121C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W RPE1^YJL121C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• SER3^YER081W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W PDC5^YLR134W MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER33^YIL074C PDC1^YLR044C PDC5^YLR134W
• succinate
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER3^YER081W PDC6^YGR087C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C RPE1^YJL121C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C RPE1^YJL121C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• SER3^YER081W PDC6^YGR087C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W PDC6^YGR087C MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER33^YIL074C PDC1^YLR044C ZWF1^YNL241C
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W PDC6^YGR087C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W PDC6^YGR087C PDC5^YLR134W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• PDC6^YGR087C SER33^YIL074C PDC5^YLR134W
• succinate
• SER3^YER081W RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER3^YER081W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER3^YER081W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER3^YER081W RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W RPE1^YJL121C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W RPE1^YJL121C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• SER3^YER081W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W PDC1^YLR044C MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• PDC6^YGR087C SER33^YIL074C ZWF1^YNL241C
• succinate
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER33^YIL074C PDC5^YLR134W ZWF1^YNL241C
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W PDC6^YGR087C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER3^YER081W PDC6^YGR087C PDC1^YLR044C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC6^YGR087C PDC1^YLR044C
• succinate
• SER33^YIL074C RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER33^YIL074C RPE1^YJL121C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C RPE1^YJL121C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C RPE1^YJL121C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C RPE1^YJL121C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C RPE1^YJL121C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• SER33^YIL074C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER33^YIL074C PDC5^YLR134W MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC1^YLR044C PDC5^YLR134W
• succinate
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• PDC6^YGR087C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• PDC6^YGR087C SER33^YIL074C MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC1^YLR044C ZWF1^YNL241C
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC6^YGR087C SER33^YIL074C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• PDC6^YGR087C SER33^YIL074C PDC5^YLR134W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC6^YGR087C PDC5^YLR134W
• succinate
• SER33^YIL074C RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER33^YIL074C RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C RPE1^YJL121C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C YJL045W^YJL045W RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C YJL045W^YJL045W RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C RPE1^YJL121C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C RPE1^YJL121C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C RPE1^YJL121C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]
• SER33^YIL074C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER33^YIL074C PDC1^YLR044C MET17^YLR303W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC6^YGR087C ZWF1^YNL241C
• succinate
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• SER33^YIL074C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC5^YLR134W ZWF1^YNL241C
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PGI1^YBR196C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4516, FVA~min~R_EX_succ_e_ (pFBA)=0,7789]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC6^YGR087C SER33^YIL074C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• PDC6^YGR087C SER33^YIL074C PDC1^YLR044C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W SER33^YIL074C FBP1^YLR377C
• succinate
• SDH2^YLL041C [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,1045, FVA~min~R_EX_succ_e_ (pFBA)=0,1794]
• SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• SDH4^YDR178W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0896, FVA~min~R_EX_succ_e_ (pFBA)=0,1536]
• malate
• NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• CDC19^YAL038W PYK2^YOR347C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1428, FVA~min~R_EX_fum_e_ (pFBA)=0,2463]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER33^YIL074C MET2^YNL277W FUM1^YPL262W
• succinate
• SER3^YER081W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH3^YKL141W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SDH2^YLL041C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• fumarate
• SER3^YER081W ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• GLY1^YEL046C SER3^YER081W MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W MAE1^YKL029C ZWF1^YNL241C LSC1^YOR142W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W MAE1^YKL029C CAR2^YLR438W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• GLY1^YEL046C SER3^YER081W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER3^YER081W MET2^YNL277W FUM1^YPL262W
• succinate
• SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH3^YKL141W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER33^YIL074C SDH2^YLL041C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• fumarate
• SER33^YIL074C ZWF1^YNL241C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• GLY1^YEL046C SER33^YIL074C MAE1^YKL029C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C LSC1^YOR142W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• GLY1^YEL046C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GLY1^YEL046C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• ZWF1^YNL241C MET2^YNL277W FUM1^YPL262W
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4485, FVA~min~R_EX_succ_e_ (pFBA)=0,7731]
• fumarate
• SER3^YER081W SER33^YIL074C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C MAE1^YKL029C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C LSC1^YOR142W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER33^YIL074C RPE1^YJL121C PDC1^YLR044C
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W PDC6^YGR087C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]

---

• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C
• succinate
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]

---

• SER33^YIL074C RPE1^YJL121C PDC5^YLR134W
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W PDC6^YGR087C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]

---

• SER3^YER081W RPE1^YJL121C PDC1^YLR044C
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC6^YGR087C SER33^YIL074C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]

---

• SER3^YER081W PDC6^YGR087C RPE1^YJL121C
• succinate
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]

---

• SER3^YER081W RPE1^YJL121C PDC5^YLR134W
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_succ_e_ (pFBA)=0,7727]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PDC6^YGR087C SER33^YIL074C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4315, FVA~min~R_EX_fum_e_ (pFBA)=0,7442]

---

• ARO3^YDR035W MAE1^YKL029C ZWF1^YNL241C
• malate
• PDA1^YER178W AGX1^YFL030W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W PDX1^YGR193C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C AGX1^YFL030W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MDH1^YKL085W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C AGX1^YFL030W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4480, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7242]
• KGD2^YDR148C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• LSC2^YGR244C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• LSC2^YGR244C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• BAT1^YHR208W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• BAT1^YHR208W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• BAT1^YHR208W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4181, FVA~min~R_EX_fum_e_ (pFBA)=0,7212]
• PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7242]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C IDP2^YLR174W MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]

---

• ARO3^YDR035W SER3^YER081W SER33^YIL074C
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0751, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0655, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• KGD2^YDR148C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GLY1^YEL046C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• PGI1^YBR196C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C MAE1^YKL029C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GLY1^YEL046C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• PGI1^YBR196C KGD2^YDR148C MAE1^YKL029C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C KGD1^YIL125W MAE1^YKL029C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• GLY1^YEL046C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• ACH1^YBL015W GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0817, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• GPD1^YDL022W MAE1^YKL029C IDP2^YLR174W MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C GPP1^YIL053W RPE1^YJL121C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C GPD2^YOL059W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C GPD2^YOL059W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]

---

• SER3^YER081W SER33^YIL074C MDH1^YKL085W
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0200, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0767, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4598, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C MET17^YLR303W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0751, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W MAE1^YKL029C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0179, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MAE1^YKL029C AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4118, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W MAE1^YKL029C AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,6207, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W MAE1^YKL029C AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W ARO3^YDR035W MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0655, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MAE1^YKL029C AAT2^YLR027C CAR2^YLR438W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C BAT1^YHR208W AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER33^YIL074C MAE1^YKL029C MET17^YLR303W
• malate
• SER3^YER081W IRC7^YFR055W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C SER3^YER081W BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• PGI1^YBR196C ARO3^YDR035W SER3^YER081W LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C ARO3^YDR035W SER3^YER081W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER3^YER081W BAT1^YHR208W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C SER3^YER081W CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• GLY1^YEL046C SER3^YER081W BAT1^YHR208W SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• PGI1^YBR196C ARO3^YDR035W KGD2^YDR148C SER3^YER081W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C ARO3^YDR035W SER3^YER081W KGD1^YIL125W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W BAT1^YHR208W ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• ARO3^YDR035W SER33^YIL074C MAE1^YKL029C
• malate
• SER3^YER081W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0751, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W SER3^YER081W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0655, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W RPE1^YJL121C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MDH1^YKL085W AAT2^YLR027C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• KGD2^YDR148C SER3^YER081W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GLY1^YEL046C SER3^YER081W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C SER3^YER081W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• SER3^YER081W KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C SER3^YER081W MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GLY1^YEL046C SER3^YER081W ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• GLY1^YEL046C SER3^YER081W ACP1^YKL192C NDI1^YML120C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• ACH1^YBL015W GLY1^YEL046C SER3^YER081W BAT1^YHR208W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0817, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• GPD1^YDL022W SER3^YER081W IDP2^YLR174W MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C SER3^YER081W GPP1^YIL053W RPE1^YJL121C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C GPD2^YOL059W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• SER3^YER081W BAT1^YHR208W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C GPD2^YOL059W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W SER3^YER081W BAT1^YHR208W ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]

---

• SER3^YER081W MAE1^YKL029C MET17^YLR303W
• malate
• IRC7^YFR055W SER33^YIL074C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• ARO3^YDR035W GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• PGI1^YBR196C ARO3^YDR035W LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C ARO3^YDR035W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C LSC2^YGR244C SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C BAT1^YHR208W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C SER33^YIL074C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• GLY1^YEL046C BAT1^YHR208W SER33^YIL074C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• PGI1^YBR196C ARO3^YDR035W KGD2^YDR148C SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C ARO3^YDR035W SER33^YIL074C KGD1^YIL125W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• GPD1^YDL022W ARO3^YDR035W SER33^YIL074C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• ARO3^YDR035W SER3^YER081W MAE1^YKL029C
• malate
• SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0751, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0655, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• KGD2^YDR148C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GLY1^YEL046C SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• SER33^YIL074C KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• PGI1^YBR196C LSC2^YGR244C SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C SER33^YIL074C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GLY1^YEL046C SER33^YIL074C ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• GLY1^YEL046C SER33^YIL074C ACP1^YKL192C NDI1^YML120C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• ACH1^YBL015W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0817, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• GPD1^YDL022W SER33^YIL074C IDP2^YLR174W MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C GPP1^YIL053W SER33^YIL074C RPE1^YJL121C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C GPD2^YOL059W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• BAT1^YHR208W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C GPD2^YOL059W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]

---

• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C
• malate
• SER3^YER081W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W MDH1^YKL085W AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W MDH1^YKL085W AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W RPE1^YJL121C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W RPE1^YJL121C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W ILV1^YER086W RPE1^YJL121C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• KGD2^YDR148C SER3^YER081W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PRO1^YDR300C GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• GLY1^YEL046C SER3^YER081W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C SER3^YER081W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• SER3^YER081W LSC2^YGR244C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER3^YER081W LSC2^YGR244C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W RPE1^YJL121C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER3^YER081W ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PGI1^YBR196C KGD2^YDR148C PRO1^YDR300C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C PRO1^YDR300C SER3^YER081W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C SER3^YER081W MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• ARO3^YDR035W KGD2^YDR148C SER3^YER081W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER3^YER081W KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER3^YER081W ZWF1^YNL241C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• PRO1^YDR300C SER3^YER081W LSC2^YGR244C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]

---

• SER3^YER081W BAT1^YHR208W MAE1^YKL029C
• malate
• SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W SER33^YIL074C RPE1^YJL121C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• KGD2^YDR148C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PRO1^YDR300C GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• GLY1^YEL046C SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C SER33^YIL074C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• LSC2^YGR244C SER33^YIL074C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• LSC2^YGR244C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C RPE1^YJL121C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER33^YIL074C ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PGI1^YBR196C KGD2^YDR148C PRO1^YDR300C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C PRO1^YDR300C SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C LSC2^YGR244C SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C SER33^YIL074C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• ARO3^YDR035W KGD2^YDR148C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER33^YIL074C KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER33^YIL074C ZWF1^YNL241C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• PRO1^YDR300C LSC2^YGR244C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]

---

• PGI1^YBR196C SER33^YIL074C ZWF1^YNL241C
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• fumarate
• SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4441, FVA~min~R_EX_fum_e_ (pFBA)=0,7660]
• SER3^YER081W MAE1^YKL029C AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_fum_e_ (pFBA)=0,7666]

---

• PGI1^YBR196C SER3^YER081W ZWF1^YNL241C
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4586, FVA~min~R_EX_succ_e_ (pFBA)=0,7910]
• fumarate
• SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4441, FVA~min~R_EX_fum_e_ (pFBA)=0,7660]
• SER33^YIL074C MAE1^YKL029C AAT1^YKL106W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_fum_e_ (pFBA)=0,7666]

---

• SER3^YER081W SER33^YIL074C LEU4^YNL104C
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4323, FVA~min~R_EX_fum_e_ (pFBA)=0,7456]
• IPP1^YBR011C TPI1^YDR050C SHM2^YLR058C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C
• malate
• TPI1^YDR050C SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W ILV1^YER086W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4160, FVA~min~R_EX_fum_e_ (pFBA)=0,7175]
• KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4160, FVA~min~R_EX_fum_e_ (pFBA)=0,7175]
• ARO3^YDR035W LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• ARO3^YDR035W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER3^YER081W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• MAE1^YKL029C ZWF1^YNL241C MET2^YNL277W
• malate
• AGX1^YFL030W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4442, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W IRC7^YFR055W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4470, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W IRC7^YFR055W SER33^YIL074C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C IRC7^YFR055W BAT1^YHR208W MDH1^YKL085W AAT1^YKL106W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W BAT1^YHR208W MDH1^YKL085W AAT1^YKL106W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W TRX2^YGR209C BAT1^YHR208W MDH1^YKL085W AAT1^YKL106W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W BAT1^YHR208W MDH1^YKL085W AAT1^YKL106W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER33^YIL074C MAE1^YKL029C MET2^YNL277W
• malate
• SER3^YER081W IRC7^YFR055W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W IRC7^YFR055W MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C SER3^YER081W BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• SER3^YER081W LSC2^YGR244C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER3^YER081W ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• GLY1^YEL046C SER3^YER081W ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C KGD1^YIL125W SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER3^YER081W MAE1^YKL029C MET2^YNL277W
• malate
• IRC7^YFR055W SER33^YIL074C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W SER33^YIL074C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• GLY1^YEL046C BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• LSC2^YGR244C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• SER33^YIL074C ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7528]
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• GLY1^YEL046C SER33^YIL074C ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0868, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• ARO3^YDR035W GLY1^YEL046C SER33^YIL074C ACP1^YKL192C NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C SER33^YIL074C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C SER33^YIL074C KGD1^YIL125W SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• RPE1^YJL121C MAE1^YKL029C PUT1^YLR142W
• malate
• PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4159, FVA~min~R_EX_fum_e_ (pFBA)=0,7174]
• LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4159, FVA~min~R_EX_fum_e_ (pFBA)=0,7174]
• KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4159, FVA~min~R_EX_fum_e_ (pFBA)=0,7174]
• LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4159, FVA~min~R_EX_fum_e_ (pFBA)=0,7174]
• ARO3^YDR035W KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• ARO3^YDR035W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER3^YER081W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]

---

• BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C
• malate
• PRO1^YDR300C IRC7^YFR055W MDH1^YKL085W AAT1^YKL106W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W MDH1^YKL085W AAT1^YKL106W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W AAT1^YKL106W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W MDH1^YKL085W AAT1^YKL106W TRX1^YLR043C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• PRO1^YDR300C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• ARO3^YDR035W KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• ARO3^YDR035W LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• ARO3^YDR035W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• ARO3^YDR035W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• ARO3^YDR035W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4181, FVA~min~R_EX_fum_e_ (pFBA)=0,7212]
• PRO1^YDR300C LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• PRO1^YDR300C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• DIT1^YDR403W LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• DIT1^YDR403W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4198, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• ARO3^YDR035W KGD2^YDR148C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• ARO3^YDR035W MAE1^YKL029C MET17^YLR303W
• malate
• IRC7^YFR055W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0265, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C SER3^YER081W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C SER3^YER081W SER33^YIL074C KGD1^YIL125W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• KGD2^YDR148C NQM1^YGR043C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• SER33^YIL074C RPE1^YJL121C MAE1^YKL029C
• malate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W BAT1^YHR208W MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W ILV1^YER086W BAT1^YHR208W MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER3^YER081W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER3^YER081W LSC2^YGR244C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER3^YER081W BAT1^YHR208W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER3^YER081W PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• SER3^YER081W RPE1^YJL121C MAE1^YKL029C
• malate
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• LSC2^YGR244C SER33^YIL074C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• BAT1^YHR208W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER33^YIL074C PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• RPE1^YJL121C MAE1^YKL029C CAR2^YLR438W
• malate
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7176]
• KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7176]

---

• MAE1^YKL029C CAR2^YLR438W ZWF1^YNL241C
• malate
• SER3^YER081W AGX1^YFL030W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7241]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W IDP2^YLR174W MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• SER3^YER081W SER33^YIL074C AAT2^YLR027C
• succinate
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0767, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0751, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4118, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0655, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W CAR2^YLR438W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ALT2^YDR111C AGX1^YFL030W TDH3^YGR192C TDH1^YJL052W TDH2^YJR009C MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,6154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C BAT1^YHR208W MDH1^YKL085W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER33^YIL074C MDH1^YKL085W AAT2^YLR027C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• SER3^YER081W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0767, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W SER3^YER081W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0751, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4118, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W BAT1^YHR208W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W ARO3^YDR035W SER3^YER081W MAE1^YKL029C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0655, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W BAT1^YHR208W MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W MAE1^YKL029C CAR2^YLR438W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W ILV1^YER086W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ALT2^YDR111C SER3^YER081W AGX1^YFL030W TDH3^YGR192C TDH1^YJL052W TDH2^YJR009C MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,6154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W MDH1^YKL085W AAT2^YLR027C
• succinate
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0767, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0751, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4118, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C AGX1^YFL030W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CDC19^YAL038W ARO3^YDR035W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C PYK2^YOR347C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0655, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W SER33^YIL074C MAE1^YKL029C CAR2^YLR438W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W BAT1^YHR208W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W BAT1^YHR208W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ALT2^YDR111C AGX1^YFL030W TDH3^YGR192C SER33^YIL074C TDH1^YJL052W TDH2^YJR009C MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,6154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C SER3^YER081W SER33^YIL074C
• succinate
• SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SDH3^YKL141W SHM2^YLR058C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SDH3^YKL141W MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SDH3^YKL141W MET2^YNL277W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SDH1^YKL148C SHM2^YLR058C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SDH1^YKL148C MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• YJL045W^YJL045W SDH1^YKL148C MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• YJL045W^YJL045W SDH1^YKL148C MET2^YNL277W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• YJL045W^YJL045W SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• malate
• AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• SHM2^YLR058C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SHM2^YLR058C MET17^YLR303W CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• GDH2^YDL215C GRE3^YHR104W MTD1^YKR080W PUT1^YLR142W GRE2^YOL151W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2438, FVA~min~R_EX_fum_e_ (pFBA)=0,4202]
• BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]
• IPP1^YBR011C GDH2^YDL215C GRE3^YHR104W MTD1^YKR080W PUT1^YLR142W GRE2^YOL151W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2381, FVA~min~R_EX_fum_e_ (pFBA)=0,4102]

---

• MAE1^YKL029C PUT1^YLR142W ZWF1^YNL241C
• malate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4197, FVA~min~R_EX_fum_e_ (pFBA)=0,7240]
• LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4197, FVA~min~R_EX_fum_e_ (pFBA)=0,7240]
• KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4197, FVA~min~R_EX_fum_e_ (pFBA)=0,7240]
• LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4197, FVA~min~R_EX_fum_e_ (pFBA)=0,7240]
• ARO3^YDR035W LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• ARO3^YDR035W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7242]

---

• PGI1^YBR196C PDC6^YGR087C PDC1^YLR044C
• succinate
• SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4429, FVA~min~R_EX_succ_e_ (pFBA)=0,7640]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• malate
• AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PGI1^YBR196C PDC1^YLR044C PDC5^YLR134W
• succinate
• PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• PDC6^YGR087C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4429, FVA~min~R_EX_succ_e_ (pFBA)=0,7640]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• malate
• AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PGI1^YBR196C PDC6^YGR087C PDC5^YLR134W
• succinate
• SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2970, FVA~min~R_EX_succ_e_ (pFBA)=0,5121]
• SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4429, FVA~min~R_EX_succ_e_ (pFBA)=0,7640]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• ACH1^YBL015W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• malate
• AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C MAE1^YKL029C CAR2^YLR438W
• malate
• SER3^YER081W AGX1^YFL030W MDH1^YKL085W AAT2^YLR027C LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W RPE1^YJL121C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C SER3^YER081W LPD1^YFL018C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• KGD2^YDR148C SER3^YER081W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER3^YER081W MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C ARO3^YDR035W KGD2^YDR148C SER3^YER081W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C ARO3^YDR035W SER3^YER081W KGD1^YIL125W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W MAE1^YKL029C CAR2^YLR438W
• malate
• AGX1^YFL030W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1408]
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PGI1^YBR196C LPD1^YFL018C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• ARO3^YDR035W GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• KGD2^YDR148C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C LSC2^YGR244C SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER33^YIL074C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C ARO3^YDR035W KGD2^YDR148C SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C ARO3^YDR035W SER33^YIL074C KGD1^YIL125W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C SER33^YIL074C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER33^YIL074C RPE1^YJL121C LEU4^YNL104C
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4323, FVA~min~R_EX_fum_e_ (pFBA)=0,7456]

---

• SER3^YER081W RPE1^YJL121C LEU4^YNL104C
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,4323, FVA~min~R_EX_fum_e_ (pFBA)=0,7456]

---

• SER3^YER081W SER33^YIL074C SHM2^YLR058C
• succinate
• TPI1^YDR050C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• FBA1^YKL060C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,1045, FVA~min~R_EX_succ_e_ (pFBA)=0,1794]
• SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,1045, FVA~min~R_EX_succ_e_ (pFBA)=0,1794]
• TPI1^YDR050C SDH4^YDR178W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH4^YDR178W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH4^YDR178W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH4^YDR178W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• TPI1^YDR050C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W FBA1^YKL060C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1045, FVA~min~R_EX_succ_e_ (pFBA)=0,1794]
• SDH4^YDR178W FBA1^YKL060C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1045, FVA~min~R_EX_succ_e_ (pFBA)=0,1794]
• SDH4^YDR178W FBA1^YKL060C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1045, FVA~min~R_EX_succ_e_ (pFBA)=0,1794]
• SDH4^YDR178W FBA1^YKL060C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1045, FVA~min~R_EX_succ_e_ (pFBA)=0,1794]
• fumarate
• PGI1^YBR196C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3168, FVA~min~R_EX_fum_e_ (pFBA)=0,5464]
• TPI1^YDR050C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• GLY1^YEL046C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• TPI1^YDR050C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• IPP1^YBR011C TPI1^YDR050C MET17^YLR303W CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• TPI1^YDR050C BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• PDC6^YGR087C PDC1^YLR044C MET17^YLR303W
• succinate
• TPI1^YDR050C SDH2^YLL041C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• fumarate
• SER3^YER081W SER33^YIL074C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• PDC1^YLR044C PDC5^YLR134W MET17^YLR303W
• succinate
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C LEU4^YNL104C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• fumarate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• PDC6^YGR087C PDC5^YLR134W MET17^YLR303W
• succinate
• TPI1^YDR050C SDH2^YLL041C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• fumarate
• SER3^YER081W SER33^YIL074C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• ACH1^YBL015W PDC6^YGR087C PDC1^YLR044C
• succinate
• PGI1^YBR196C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• RPE1^YJL121C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• FBA1^YKL060C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• PGI1^YBR196C SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• GDH2^YDL215C MTD1^YKR080W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3693, FVA~min~R_EX_succ_e_ (pFBA)=0,6281]
• SDH4^YDR178W RPE1^YJL121C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• SDH4^YDR178W RPE1^YJL121C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• fumarate
• UGA2^YBR006W GDH2^YDL215C ALD5^YER073W HXK1^YFR053C HXK2^YGL253W MTD1^YKR080W PDC5^YLR134W ALD4^YOR374W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5237, FVA~min~R_EX_fum_e_ (pFBA)=0,9024]

---

• ACH1^YBL015W PDC1^YLR044C PDC5^YLR134W
• succinate
• PGI1^YBR196C PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PDC6^YGR087C RPE1^YJL121C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• PDC6^YGR087C FBA1^YKL060C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• PDC6^YGR087C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• PDC6^YGR087C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• PGI1^YBR196C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C PDC6^YGR087C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• GDH2^YDL215C PDC6^YGR087C MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3693, FVA~min~R_EX_succ_e_ (pFBA)=0,6281]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• SDH4^YDR178W PDC6^YGR087C RPE1^YJL121C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• fumarate
• UGA2^YBR006W GDH2^YDL215C ALD5^YER073W HXK1^YFR053C HXK2^YGL253W PDC6^YGR087C MTD1^YKR080W ALD4^YOR374W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5237, FVA~min~R_EX_fum_e_ (pFBA)=0,9024]

---

• ACH1^YBL015W PDC6^YGR087C PDC5^YLR134W
• succinate
• PGI1^YBR196C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• RPE1^YJL121C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• FBA1^YKL060C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4445, FVA~min~R_EX_succ_e_ (pFBA)=0,7666]
• PGI1^YBR196C SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• PGI1^YBR196C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3057, FVA~min~R_EX_succ_e_ (pFBA)=0,5272]
• GDH2^YDL215C MTD1^YKR080W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3693, FVA~min~R_EX_succ_e_ (pFBA)=0,6281]
• SDH4^YDR178W RPE1^YJL121C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• SDH4^YDR178W RPE1^YJL121C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4409, FVA~min~R_EX_succ_e_ (pFBA)=0,7604]
• fumarate
• UGA2^YBR006W GDH2^YDL215C ALD5^YER073W HXK1^YFR053C HXK2^YGL253W MTD1^YKR080W PDC1^YLR044C ALD4^YOR374W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5237, FVA~min~R_EX_fum_e_ (pFBA)=0,9024]

---

• BAT1^YHR208W SER33^YIL074C RPE1^YJL121C
• malate
• TPI1^YDR050C SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W ILV1^YER086W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• SER3^YER081W BAT1^YHR208W RPE1^YJL121C
• malate
• TPI1^YDR050C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7440]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• BAT1^YHR208W MAE1^YKL029C MET2^YNL277W
• malate
• DIT1^YDR403W IRC7^YFR055W MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0257, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C IRC7^YFR055W MDH1^YKL085W AAT1^YKL106W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W MDH1^YKL085W AAT1^YKL106W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W AAT1^YKL106W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W MDH1^YKL085W AAT1^YKL106W TRX1^YLR043C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• ARO3^YDR035W RPE1^YJL121C MAE1^YKL029C
• malate
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• LSC2^YGR244C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• BAT1^YHR208W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• KGD1^YIL125W PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• ARO3^YDR035W SER33^YIL074C MET17^YLR303W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• ARO3^YDR035W SER3^YER081W MET17^YLR303W
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• PGI1^YBR196C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5339]
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C
• malate
• MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0204, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• DIT1^YDR403W IRC7^YFR055W MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0257, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W SER33^YIL074C MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W ILV1^YER086W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• ARO3^YDR035W MAE1^YKL029C CAR2^YLR438W
• malate
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PGI1^YBR196C KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2911, FVA~min~R_EX_fum_e_ (pFBA)=0,5021]
• PGI1^YBR196C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2911, FVA~min~R_EX_fum_e_ (pFBA)=0,5021]
• GLY1^YEL046C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C SER3^YER081W SER33^YIL074C KGD1^YIL125W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]

---

• ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C
• malate
• MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0204, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• FUM1^YPL262W [#knockouts (pFBA)=4,0000, CYIELD (pFBA)=0,0204, FVA~min~R_EX_fum_e_ (pFBA)=0,0349]
• GLY1^YEL046C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0232, FVA~min~R_EX_fum_e_ (pFBA)=0,0397]
• KGD2^YDR148C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• LSC2^YGR244C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• LSC2^YGR244C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• RPE1^YJL121C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4181, FVA~min~R_EX_fum_e_ (pFBA)=0,7212]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPP2^YER062C GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• ACH1^YBL015W GLY1^YEL046C SER3^YER081W SER33^YIL074C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0817, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• GPD1^YDL022W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLT1^YDL171C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]

---

• SER3^YER081W SER33^YIL074C TAL1^YLR354C
• succinate
• NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SDH2^YLL041C MET17^YLR303W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• malate
• NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W NQM1^YGR043C SER33^YIL074C
• succinate
• SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH2^YLL041C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• malate
• MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• NQM1^YGR043C SER33^YIL074C TAL1^YLR354C
• succinate
• SER3^YER081W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH2^YLL041C MET17^YLR303W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH2^YLL041C FBP1^YLR377C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER33^YIL074C TAL1^YLR354C FBP1^YLR377C
• succinate
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• malate
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C MET17^YLR303W CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C SRY1^YKL218C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• NQM1^YGR043C SER33^YIL074C FBP1^YLR377C
• succinate
• SER3^YER081W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH3^YKL141W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH2^YLL041C MET17^YLR303W TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH2^YLL041C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER3^YER081W SDH2^YLL041C TAL1^YLR354C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W NQM1^YGR043C TAL1^YLR354C
• succinate
• SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH2^YLL041C MET17^YLR303W FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH2^YLL041C FBP1^YLR377C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W TAL1^YLR354C FBP1^YLR377C
• succinate
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• malate
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MET17^YLR303W CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W NQM1^YGR043C FBP1^YLR377C
• succinate
• SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH3^YKL141W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH2^YLL041C MET17^YLR303W TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH2^YLL041C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SER33^YIL074C SDH2^YLL041C TAL1^YLR354C MET2^YNL277W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2625, FVA~min~R_EX_succ_e_ (pFBA)=0,4521]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER33^YIL074C PDC1^YLR044C MET17^YLR303W
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• SER3^YER081W PDC6^YGR087C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]

---

• PDC6^YGR087C SER33^YIL074C MET17^YLR303W
• succinate
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• SER3^YER081W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]

---

• SER33^YIL074C PDC5^YLR134W MET17^YLR303W
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• SER3^YER081W PDC6^YGR087C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]

---

• SER3^YER081W PDC1^YLR044C MET17^YLR303W
• succinate
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• PDC6^YGR087C SER33^YIL074C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]

---

• SER3^YER081W PDC6^YGR087C MET17^YLR303W
• succinate
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• SER33^YIL074C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]

---

• SER3^YER081W PDC5^YLR134W MET17^YLR303W
• succinate
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0969, FVA~min~R_EX_succ_e_ (pFBA)=0,1670]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0929, FVA~min~R_EX_succ_e_ (pFBA)=0,1601]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• PDC6^YGR087C SER33^YIL074C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]

---

• PDC1^YLR044C MET17^YLR303W ZWF1^YNL241C
• succinate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• PDC6^YGR087C MET17^YLR303W ZWF1^YNL241C
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• PDC5^YLR134W MET17^YLR303W ZWF1^YNL241C
• succinate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• fumarate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4367, FVA~min~R_EX_fum_e_ (pFBA)=0,7532]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C
• succinate
• TPI1^YDR050C ALT2^YDR111C SDH2^YLL041C PDC5^YLR134W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W
• succinate
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SDH2^YLL041C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SDH2^YLL041C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W
• succinate
• TPI1^YDR050C ALT2^YDR111C SDH2^YLL041C PDC1^YLR044C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C IDH1^YNL037C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C MET2^YNL277W IDH2^YOR136W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C PDC1^YLR044C FBP1^YLR377C
• succinate
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• malate
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C
• succinate
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C PDC5^YLR134W FBP1^YLR377C
• succinate
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• ACH1^YBL015W SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0801, FVA~min~R_EX_succ_e_ (pFBA)=0,1379]
• malate
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C
• succinate
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• malate
• RPE1^YJL121C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MDH1^YKL085W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W MDH1^YKL085W PDC5^YLR134W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C SOR1^YJR159W MDH1^YKL085W MTD1^YKR080W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W
• succinate
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• malate
• PDC6^YGR087C RPE1^YJL121C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C PDC6^YGR087C SOR1^YJR159W MDH1^YKL085W MTD1^YKR080W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W
• succinate
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0062, FVA~min~R_EX_succ_e_ (pFBA)=0,0104]
• malate
• RPE1^YJL121C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MDH1^YKL085W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W MDH1^YKL085W PDC1^YLR044C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C SOR1^YJR159W MDH1^YKL085W MTD1^YKR080W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• ARO3^YDR035W SER33^YIL074C ZWF1^YNL241C
• malate
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C IDP2^YLR174W MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C GPD2^YOL059W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C GPD2^YOL059W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C MET2^YNL277W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W MET17^YLR303W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W MET17^YLR303W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W MET17^YLR303W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]

---

• ARO3^YDR035W SER3^YER081W ZWF1^YNL241C
• malate
• TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C GPD2^YOL059W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C GPD2^YOL059W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C MET2^YNL277W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W MET17^YLR303W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W MET17^YLR303W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W MET17^YLR303W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]

---

• PDC6^YGR087C PDC1^YLR044C MET2^YNL277W
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C ALT2^YDR111C BAT1^YHR208W SDH2^YLL041C PDC5^YLR134W IDH1^YNL037C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C BAT1^YHR208W SDH2^YLL041C PDC5^YLR134W IDH2^YOR136W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• malate
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC1^YLR044C PDC5^YLR134W MET2^YNL277W
• succinate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C IDH1^YNL037C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C IDH2^YOR136W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• malate
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C PDC5^YLR134W MET2^YNL277W
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C ALT2^YDR111C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C IDH1^YNL037C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C ALT2^YDR111C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C IDH2^YOR136W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_succ_e_ (pFBA)=0,1254]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• malate
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• BAT1^YHR208W ZWF1^YNL241C MET2^YNL277W
• malate
• PRO1^YDR300C IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W TSA2^YDR453C IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]

---

• SER3^YER081W SER33^YIL074C IDP2^YLR174W
• malate
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• UGA2^YBR006W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4795, FVA~min~R_EX_fum_e_ (pFBA)=0,8269]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W RPE1^YJL121C MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W RPE1^YJL121C MAE1^YKL029C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]

---

• SER33^YIL074C IDP2^YLR174W ZWF1^YNL241C
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• UGA2^YBR006W SER3^YER081W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4795, FVA~min~R_EX_fum_e_ (pFBA)=0,8269]
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W MAE1^YKL029C MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C MET2^YNL277W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER3^YER081W IDP2^YLR174W ZWF1^YNL241C
• malate
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• UGA2^YBR006W SER33^YIL074C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4795, FVA~min~R_EX_fum_e_ (pFBA)=0,8269]
• GPD1^YDL022W ARO3^YDR035W SER33^YIL074C MAE1^YKL029C MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C MET2^YNL277W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER33^YIL074C MAE1^YKL029C PUT1^YLR142W
• malate
• SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C SER3^YER081W LPD1^YFL018C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C SER3^YER081W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• SER3^YER081W LSC2^YGR244C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER3^YER081W RPE1^YJL121C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]

---

• SER3^YER081W MAE1^YKL029C PUT1^YLR142W
• malate
• PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C LPD1^YFL018C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• PGI1^YBR196C LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• LSC2^YGR244C SER33^YIL074C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER33^YIL074C RPE1^YJL121C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]

---

• SER3^YER081W SER33^YIL074C PUT1^YLR142W
• malate
• PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• PGI1^YBR196C KGD2^YDR148C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C LPD1^YFL018C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• PGI1^YBR196C LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• PGI1^YBR196C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• GDH2^YDL215C GRE3^YHR104W MTD1^YKR080W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3924, FVA~min~R_EX_fum_e_ (pFBA)=0,6764]
• GDH2^YDL215C SOR1^YJR159W MTD1^YKR080W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3924, FVA~min~R_EX_fum_e_ (pFBA)=0,6764]
• LSC2^YGR244C RPE1^YJL121C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• RPE1^YJL121C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• GDH2^YDL215C HXK1^YFR053C HXK2^YGL253W MTD1^YKR080W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3924, FVA~min~R_EX_fum_e_ (pFBA)=0,6764]
• ACH1^YBL015W GDH2^YDL215C MTD1^YKR080W IDH1^YNL037C ALD4^YOR374W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0654, FVA~min~R_EX_fum_e_ (pFBA)=0,1125]
• ACH1^YBL015W GDH2^YDL215C MTD1^YKR080W IDH2^YOR136W ALD4^YOR374W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0654, FVA~min~R_EX_fum_e_ (pFBA)=0,1125]
• GDH2^YDL215C TPI1^YDR050C GRE3^YHR104W MTD1^YKR080W GRE2^YOL151W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2438, FVA~min~R_EX_fum_e_ (pFBA)=0,4202]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• IPP1^YBR011C GDH2^YDL215C TPI1^YDR050C GRE3^YHR104W MTD1^YKR080W GRE2^YOL151W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2381, FVA~min~R_EX_fum_e_ (pFBA)=0,4102]

---

• SER33^YIL074C RPE1^YJL121C PUT1^YLR142W
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]

---

• SER3^YER081W RPE1^YJL121C PUT1^YLR142W
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]
• SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4313, FVA~min~R_EX_fum_e_ (pFBA)=0,7438]

---

• MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W SER33^YIL074C MET17^YLR303W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W CAR2^YLR438W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MET17^YLR303W CAR2^YLR438W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• ARO3^YDR035W PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W BAT1^YHR208W ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]

---

• SER33^YIL074C MDH1^YKL085W MET17^YLR303W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• malate
• SER3^YER081W IRC7^YFR055W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W AAT2^YLR027C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W MDH1^YKL085W MET17^YLR303W
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• malate
• IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C AAT2^YLR027C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• ARO3^YDR035W MAE1^YKL029C PUT1^YLR142W
• malate
• PDA1^YER178W NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• LSC2^YGR244C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7243]
• KGD1^YIL125W RPE1^YJL121C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4161, FVA~min~R_EX_fum_e_ (pFBA)=0,7177]
• ZWF1^YNL241C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,4199, FVA~min~R_EX_fum_e_ (pFBA)=0,7242]
• KGD2^YDR148C NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• NQM1^YGR043C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C NQM1^YGR043C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• NQM1^YGR043C KGD1^YIL125W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• BAT1^YHR208W SER33^YIL074C MET2^YNL277W
• succinate
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER3^YER081W BAT1^YHR208W MET2^YNL277W
• succinate
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER33^YIL074C PDC1^YLR044C MET2^YNL277W
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• malate
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C SER33^YIL074C MET2^YNL277W
• succinate
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• malate
• SER3^YER081W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C PDC5^YLR134W MET2^YNL277W
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• malate
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W PDC1^YLR044C MET2^YNL277W
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• malate
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W PDC6^YGR087C MET2^YNL277W
• succinate
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• malate
• SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W PDC5^YLR134W MET2^YNL277W
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C LEU4^YNL104C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1925]
• THI3^YDL080C ARO10^YDR380W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• malate
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• NQM1^YGR043C TAL1^YLR354C MET2^YNL277W
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• malate
• IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W AAT1^YKL106W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2136, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• ACH1^YBL015W LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• PGI1^YBR196C MAE1^YKL029C PUT1^YLR142W
• malate
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W LAT1^YNL071W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C TRX2^YGR209C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W LAT1^YNL071W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MDH1^YKL085W TRX1^YLR043C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C LAT1^YNL071W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2909, FVA~min~R_EX_fum_e_ (pFBA)=0,5017]
• KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,2909, FVA~min~R_EX_fum_e_ (pFBA)=0,5017]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• SER3^YER081W LPD1^YFL018C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0368, FVA~min~R_EX_fum_e_ (pFBA)=0,0633]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]
• SER3^YER081W SER33^YIL074C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3077, FVA~min~R_EX_fum_e_ (pFBA)=0,5307]

---

• PDC1^YLR044C ZWF1^YNL241C MET2^YNL277W
• succinate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C ZWF1^YNL241C MET2^YNL277W
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC5^YLR134W ZWF1^YNL241C MET2^YNL277W
• succinate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• THI3^YDL080C ARO10^YDR380W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4531, FVA~min~R_EX_succ_e_ (pFBA)=0,7815]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• ARO3^YDR035W SER33^YIL074C CAR2^YLR438W
• malate
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• PGI1^YBR196C KGD2^YDR148C SER3^YER081W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C SER3^YER081W KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]

---

• ARO3^YDR035W SER3^YER081W CAR2^YLR438W
• malate
• TPI1^YDR050C AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GLY1^YEL046C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0818, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]
• PGI1^YBR196C KGD2^YDR148C SER33^YIL074C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]

---

• ARO3^YDR035W SER33^YIL074C RPE1^YJL121C
• malate
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• ARO3^YDR035W SER3^YER081W RPE1^YJL121C
• malate
• TPI1^YDR050C AGX1^YFL030W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]

---

• BAT1^YHR208W SER33^YIL074C PDC1^YLR044C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• PDC6^YGR087C BAT1^YHR208W SER33^YIL074C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• BAT1^YHR208W SER33^YIL074C PDC5^YLR134W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W BAT1^YHR208W PDC1^YLR044C
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC6^YGR087C BAT1^YHR208W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C NQM1^YGR043C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W BAT1^YHR208W PDC5^YLR134W
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C
• malate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C MAE1^YKL029C ZWF1^YNL241C
• malate
• SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C
• malate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• TPI1^YDR050C SER33^YIL074C MET17^YLR303W
• succinate
• SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER3^YER081W SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER3^YER081W SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER3^YER081W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• IPP1^YBR011C SER3^YER081W SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• malate
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• SER3^YER081W SHM2^YLR058C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER3^YER081W SHM2^YLR058C CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• SER3^YER081W BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C SER3^YER081W MET17^YLR303W
• succinate
• SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER33^YIL074C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• IPP1^YBR011C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0923, FVA~min~R_EX_succ_e_ (pFBA)=0,1584]
• malate
• ARO3^YDR035W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• SER33^YIL074C SHM2^YLR058C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER33^YIL074C SHM2^YLR058C CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• BAT1^YHR208W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• PGI1^YBR196C SER33^YIL074C MET2^YNL277W
• succinate
• GDH2^YDL215C SER3^YER081W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W SDH3^YKL141W MTD1^YKR080W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W MTD1^YKR080W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER3^YER081W YJL045W^YJL045W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER3^YER081W SDH3^YKL141W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER3^YER081W SDH3^YKL141W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER3^YER081W SDH3^YKL141W MTD1^YKR080W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER3^YER081W SDH1^YKL148C MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER3^YER081W MTD1^YKR080W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER3^YER081W MTD1^YKR080W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W MTD1^YKR080W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W MTD1^YKR080W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W SDH3^YKL141W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER3^YER081W SDH3^YKL141W MTD1^YKR080W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]

---

• PGI1^YBR196C SER3^YER081W MET2^YNL277W
• succinate
• GDH2^YDL215C SER33^YIL074C MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W MTD1^YKR080W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C MTD1^YKR080W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER33^YIL074C YJL045W^YJL045W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER33^YIL074C SDH3^YKL141W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER33^YIL074C SDH3^YKL141W MTD1^YKR080W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER33^YIL074C SDH1^YKL148C MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER33^YIL074C MTD1^YKR080W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SER33^YIL074C MTD1^YKR080W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W MTD1^YKR080W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W MTD1^YKR080W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C MTD1^YKR080W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W MTD1^YKR080W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• GDH2^YDL215C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W MTD1^YKR080W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0491, FVA~min~R_EX_succ_e_ (pFBA)=0,0846]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]

---

• MDH1^YKL085W AAT2^YLR027C MET17^YLR303W
• malate
• ARO3^YDR035W IRC7^YFR055W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0265, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SER33^YIL074C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• BAT1^YHR208W SER33^YIL074C MDH1^YKL085W
• malate
• SER3^YER081W MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W MAE1^YKL029C AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W MAE1^YKL029C AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W RPE1^YJL121C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W ILV1^YER086W RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER3^YER081W AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• BAT1^YHR208W SER33^YIL074C AAT2^YLR027C
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER3^YER081W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W ILV1^YER086W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER3^YER081W MDH1^YKL085W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W BAT1^YHR208W MDH1^YKL085W
• malate
• SER33^YIL074C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER33^YIL074C MAE1^YKL029C AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER33^YIL074C AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W BAT1^YHR208W AAT2^YLR027C
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0728, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0716, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TPI1^YDR050C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3938, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C ILV1^YER086W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4262, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER33^YIL074C MDH1^YKL085W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• MAE1^YKL029C MET17^YLR303W ZWF1^YNL241C
• malate
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W SER33^YIL074C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W IDP2^YLR174W CAR2^YLR438W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7248]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• ARO3^YDR035W MET17^YLR303W ZWF1^YNL241C
• malate
• TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• TAL1^YLR354C FBP1^YLR377C MET2^YNL277W
• succinate
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• NQM1^YGR043C FBP1^YLR377C MET2^YNL277W
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• malate
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• ACH1^YBL015W LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• BAT1^YHR208W SER33^YIL074C ZWF1^YNL241C
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• ARO3^YDR035W KGD2^YDR148C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER3^YER081W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• PRO1^YDR300C SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PRO1^YDR300C SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W SER3^YER081W LSC2^YGR244C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C GPD2^YOL059W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER3^YER081W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C GPD2^YOL059W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W BAT1^YHR208W ZWF1^YNL241C
• malate
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• ARO3^YDR035W KGD2^YDR148C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• PRO1^YDR300C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• PRO1^YDR300C SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4350, FVA~min~R_EX_fum_e_ (pFBA)=0,7503]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4365, FVA~min~R_EX_fum_e_ (pFBA)=0,7529]
• GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W LSC2^YGR244C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C GPD2^YOL059W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• ARO3^YDR035W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C GPD2^YOL059W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]
• GPD1^YDL022W ARO3^YDR035W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C
• malate
• FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2114, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2559, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDA1^YER178W FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0105, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDA1^YER178W MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W AAT1^YKL106W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2136, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• PRO1^YDR300C PFK1^YGR240C BAT1^YHR208W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2021, FVA~min~R_EX_fum_e_ (pFBA)=0,3486]
• PRO1^YDR300C BAT1^YHR208W PFK2^YMR205C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2021, FVA~min~R_EX_fum_e_ (pFBA)=0,3486]
• KGD1^YIL125W PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD1^YIL125W PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ALT2^YDR111C AGX1^YFL030W LSC2^YGR244C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2447, FVA~min~R_EX_fum_e_ (pFBA)=0,4219]
• ALT2^YDR111C AGX1^YFL030W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2447, FVA~min~R_EX_fum_e_ (pFBA)=0,4219]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• BAT1^YHR208W KGD1^YIL125W FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• ARO3^YDR035W KGD2^YDR148C PUT1^YLR142W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W KGD1^YIL125W PUT1^YLR142W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W MET17^YLR303W FBP1^YLR377C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• SER3^YER081W LPD1^YFL018C SER33^YIL074C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C PUT1^YLR142W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]

---

• MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C
• malate
• NQM1^YGR043C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2559, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDA1^YER178W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ALT2^YDR111C AGX1^YFL030W NQM1^YGR043C LSC2^YGR244C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2447, FVA~min~R_EX_fum_e_ (pFBA)=0,4219]
• ALT2^YDR111C AGX1^YFL030W NQM1^YGR043C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2447, FVA~min~R_EX_fum_e_ (pFBA)=0,4219]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C PUT1^YLR142W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W MET17^YLR303W YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C SER33^YIL074C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C SER33^YIL074C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C PUT1^YLR142W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MET17^YLR303W YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W MET17^YLR303W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]

---

• NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C
• malate
• MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,2559, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDA1^YER178W MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ALT2^YDR111C AGX1^YFL030W LSC2^YGR244C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2447, FVA~min~R_EX_fum_e_ (pFBA)=0,4219]
• ALT2^YDR111C AGX1^YFL030W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2447, FVA~min~R_EX_fum_e_ (pFBA)=0,4219]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W TAL1^YLR354C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• BAT1^YHR208W KGD1^YIL125W TAL1^YLR354C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• ARO3^YDR035W KGD2^YDR148C PUT1^YLR142W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W KGD1^YIL125W PUT1^YLR142W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• SER3^YER081W LPD1^YFL018C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C PUT1^YLR142W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• BAT1^YHR208W KGD1^YIL125W MET17^YLR303W TAL1^YLR354C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C PRO1^YDR300C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]

---

• TPI1^YDR050C SER33^YIL074C MDH1^YKL085W
• succinate
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• SER3^YER081W AGX1^YFL030W MAE1^YKL029C AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C AAT2^YLR027C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W BAT1^YHR208W AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C SER3^YER081W MDH1^YKL085W
• succinate
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• AGX1^YFL030W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• BAT1^YHR208W SER33^YIL074C AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C IDP2^YLR174W ZWF1^YNL241C
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C GAD1^YMR250W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4200, FVA~min~R_EX_fum_e_ (pFBA)=0,7244]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C
• malate
• PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• IDP1^YDL066W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C
• malate
• MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• IDP1^YDL066W GPP2^YER062C GPP1^YIL053W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W BAT1^YHR208W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• RPE1^YJL121C MAE1^YKL029C PDC5^YLR134W
• malate
• PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• IDP1^YDL066W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• PDC6^YGR087C PDC1^YLR044C TAL1^YLR354C
• succinate
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W NQM1^YGR043C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH3^YKL141W PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH3^YKL141W PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C
• succinate
• IPP1^YBR011C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C
• succinate
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC1^YLR044C PDC5^YLR134W
• succinate
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC1^YLR044C TAL1^YLR354C
• succinate
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C
• succinate
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC1^YLR044C FBP1^YLR377C
• succinate
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C PDC5^YLR134W TAL1^YLR354C
• succinate
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH3^YKL141W PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC1^YLR044C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W PDC1^YLR044C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH3^YKL141W PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC1^YLR044C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC6^YGR087C PDC5^YLR134W
• succinate
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC6^YGR087C TAL1^YLR354C
• succinate
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C TAL1^YLR354C FBP1^YLR377C
• succinate
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC6^YGR087C FBP1^YLR377C
• succinate
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC5^YLR134W TAL1^YLR354C
• succinate
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C
• succinate
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC5^YLR134W FBP1^YLR377C
• succinate
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• IPP1^YBR011C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2500, FVA~min~R_EX_succ_e_ (pFBA)=0,4312]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• ACH1^YBL015W IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• malate
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C
• succinate
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER3^YER081W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C SER3^YER081W BAT1^YHR208W
• succinate
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C SER33^YIL074C AAT2^YLR027C
• succinate
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• SER3^YER081W AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W BAT1^YHR208W MDH1^YKL085W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C SER3^YER081W AAT2^YLR027C
• succinate
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• AGX1^YFL030W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C MDH1^YKL085W AAT2^YLR027C
• succinate
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• SER3^YER081W AGX1^YFL030W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5181, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W BAT1^YHR208W SER33^YIL074C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER33^YIL074C MAE1^YKL029C PDC1^YLR044C
• malate
• SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C
• malate
• SER3^YER081W MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER33^YIL074C MAE1^YKL029C PDC5^YLR134W
• malate
• SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W MAE1^YKL029C PDC1^YLR044C
• malate
• PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC6^YGR087C MAE1^YKL029C
• malate
• SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W MAE1^YKL029C PDC5^YLR134W
• malate
• PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER33^YIL074C MAE1^YKL029C IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W RPE1^YJL121C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W BAT1^YHR208W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W SER3^YER081W BAT1^YHR208W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W BAT1^YHR208W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W BAT1^YHR208W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W RPE1^YJL121C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• SER3^YER081W MAE1^YKL029C IDP2^YLR174W
• malate
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W ARO3^YDR035W SER33^YIL074C MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C RPE1^YJL121C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4316, FVA~min~R_EX_fum_e_ (pFBA)=0,7445]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W ARO3^YDR035W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W BAT1^YHR208W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C BAT1^YHR208W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C RPE1^YJL121C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• SER33^YIL074C MDH1^YKL085W MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• malate
• SER3^YER081W IRC7^YFR055W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W IRC7^YFR055W MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W BAT1^YHR208W MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W MDH1^YKL085W MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• malate
• IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0251, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4641, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MDH1^YKL085W AAT2^YLR027C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• DIT2^YDR402C MAE1^YKL029C MTD1^YKR080W MDH2^YOL126C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0220, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• DIT1^YDR403W IRC7^YFR055W BAT1^YHR208W MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0257, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• TPI1^YDR050C SER33^YIL074C CAR2^YLR438W
• succinate
• IPP1^YBR011C SER3^YER081W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SDH3^YKL141W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SHH4^YLR164W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SDH3^YKL141W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SDH3^YKL141W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SDH3^YKL141W MET17^YLR303W SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SDH1^YKL148C SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SDH2^YLL041C SHH4^YLR164W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SDH2^YLL041C MET17^YLR303W SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SHH4^YLR164W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• malate
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER3^YER081W SHM2^YLR058C MET17^YLR303W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• TPI1^YDR050C SER3^YER081W CAR2^YLR438W
• succinate
• IPP1^YBR011C SER33^YIL074C SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C SHH4^YLR164W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER33^YIL074C SDH3^YKL141W MET17^YLR303W SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER33^YIL074C SDH2^YLL041C MET17^YLR303W SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W MET17^YLR303W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• malate
• ARO3^YDR035W AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER33^YIL074C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER33^YIL074C SHM2^YLR058C MET17^YLR303W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• PGI1^YBR196C MAE1^YKL029C MET2^YNL277W
• malate
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C TRX2^YGR209C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C CAR2^YLR438W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2915, FVA~min~R_EX_fum_e_ (pFBA)=0,5027]
• LPD1^YFL018C CAR2^YLR438W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3194, FVA~min~R_EX_fum_e_ (pFBA)=0,5507]
• KGD1^YIL125W CAR2^YLR438W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2915, FVA~min~R_EX_fum_e_ (pFBA)=0,5027]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]

---

• PGI1^YBR196C SER33^YIL074C SHM2^YLR058C
• succinate
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• fumarate
• SER3^YER081W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3168, FVA~min~R_EX_fum_e_ (pFBA)=0,5464]

---

• PGI1^YBR196C SER3^YER081W SHM2^YLR058C
• succinate
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• fumarate
• SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3168, FVA~min~R_EX_fum_e_ (pFBA)=0,5464]

---

• SER33^YIL074C FBP1^YLR377C MET2^YNL277W
• succinate
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W FBP1^YLR377C MET2^YNL277W
• succinate
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER33^YIL074C PDC1^YLR044C IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• PDC6^YGR087C SER33^YIL074C IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER33^YIL074C PDC5^YLR134W IDP2^YLR174W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC1^YLR044C IDP2^YLR174W
• malate
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC6^YGR087C IDP2^YLR174W
• malate
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER3^YER081W PDC5^YLR134W IDP2^YLR174W
• malate
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4352, FVA~min~R_EX_fum_e_ (pFBA)=0,7506]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C CAR2^YLR438W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• ARO3^YDR035W GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER33^YIL074C SHM2^YLR058C MET17^YLR303W
• succinate
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W AAT1^YKL106W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SDH2^YLL041C GDH1^YOR375C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2010]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• fumarate
• PGI1^YBR196C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3168, FVA~min~R_EX_fum_e_ (pFBA)=0,5464]
• TPI1^YDR050C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• GLY1^YEL046C SER3^YER081W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• TPI1^YDR050C SER3^YER081W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W SHM2^YLR058C MET17^YLR303W
• succinate
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C AAT1^YKL106W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• GDH3^YAL062W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C GDH1^YOR375C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2010]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• fumarate
• PGI1^YBR196C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,3168, FVA~min~R_EX_fum_e_ (pFBA)=0,5464]
• TPI1^YDR050C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• GLY1^YEL046C SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• TPI1^YDR050C SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C
• succinate
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W MAE1^YKL029C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W MAE1^YKL029C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• fumarate
• IDP1^YDL066W GPP2^YER062C GPP1^YIL053W RPE1^YJL121C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W
• succinate
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH3^YKL141W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W MAE1^YKL029C SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W MAE1^YKL029C SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• fumarate
• IDP1^YDL066W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W RPE1^YJL121C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• PDC6^YGR087C SHM2^YLR058C PDC5^YLR134W
• succinate
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W MAE1^YKL029C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W MAE1^YKL029C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C MAE1^YKL029C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• fumarate
• IDP1^YDL066W GPP2^YER062C GPP1^YIL053W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W BAT1^YHR208W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• BAT1^YHR208W SER33^YIL074C MET17^YLR303W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• GLY1^YEL046C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• GLY1^YEL046C SER3^YER081W MAE1^YKL029C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• TPI1^YDR050C SER3^YER081W MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• SER3^YER081W BAT1^YHR208W MET17^YLR303W
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• GLY1^YEL046C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0867, FVA~min~R_EX_fum_e_ (pFBA)=0,1494]
• PGI1^YBR196C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• PGI1^YBR196C SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• GLY1^YEL046C SER33^YIL074C MAE1^YKL029C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• TPI1^YDR050C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• GPD1^YDL022W GLT1^YDL171C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• TPI1^YDR050C BAT1^YHR208W MDH1^YKL085W
• malate
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT2^YLR027C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W SER33^YIL074C AAT2^YLR027C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C BAT1^YHR208W AAT2^YLR027C
• malate
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,5141, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W SER33^YIL074C MDH1^YKL085W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C
• malate
• PDA1^YER178W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0105, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDA1^YER178W NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• NQM1^YGR043C KGD1^YIL125W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C SER33^YIL074C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C SER33^YIL074C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C FBP1^YLR377C MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C FBP1^YLR377C MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W
• malate
• PDA1^YER178W FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0105, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDA1^YER178W MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD2^YDR148C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W KGD1^YIL125W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• ACH1^YBL015W LSC2^YGR244C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C
• malate
• PDA1^YER178W NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• NQM1^YGR043C KGD1^YIL125W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C SER33^YIL074C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C TAL1^YLR354C MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C TAL1^YLR354C MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• NQM1^YGR043C PUT1^YLR142W TAL1^YLR354C
• malate
• PDA1^YER178W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0105, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2135, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDA1^YER178W MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• ACH1^YBL015W LSC2^YGR244C MAE1^YKL029C FBP1^YLR377C MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C
• malate
• PDA1^YER178W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C MAE1^YKL029C MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• NQM1^YGR043C PUT1^YLR142W FBP1^YLR377C
• malate
• PDA1^YER178W MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2599, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDA1^YER178W MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2440, FVA~min~R_EX_fum_e_ (pFBA)=0,4208]
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• ACH1^YBL015W LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W MAE1^YKL029C TAL1^YLR354C MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• ARO3^YDR035W PRO1^YDR300C GPP2^YER062C GPP1^YIL053W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]

---

• BAT1^YHR208W IDP2^YLR174W ZWF1^YNL241C
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• ARO3^YDR035W PRO1^YDR300C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]

---

• BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W RPE1^YJL121C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• BAT1^YHR208W PDC1^YLR044C ZWF1^YNL241C
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• BAT1^YHR208W PDC1^YLR044C IDP2^YLR174W
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C SHM2^YLR058C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C BAT1^YHR208W ZWF1^YNL241C
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C BAT1^YHR208W IDP2^YLR174W
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• BAT1^YHR208W PDC5^YLR134W ZWF1^YNL241C
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• BAT1^YHR208W PDC5^YLR134W IDP2^YLR174W
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PRO1^YDR300C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W ARO3^YDR035W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• PRO1^YDR300C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• ARO3^YDR035W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C PDC1^YLR044C LEU4^YNL104C
• succinate
• TPI1^YDR050C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• FBA1^YKL060C SDH2^YLL041C PDC5^YLR134W IDH1^YNL037C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• FBA1^YKL060C SDH2^YLL041C PDC5^YLR134W IDH2^YOR136W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• TPI1^YDR050C SDH4^YDR178W SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W FBA1^YKL060C SDH3^YKL141W PDC5^YLR134W IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W FBA1^YKL060C SDH3^YKL141W PDC5^YLR134W IDH2^YOR136W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W FBA1^YKL060C SDH1^YKL148C PDC5^YLR134W IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W FBA1^YKL060C SDH1^YKL148C PDC5^YLR134W IDH2^YOR136W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W FBA1^YKL060C SDH2^YLL041C PDC5^YLR134W IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• malate
• RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C SOR1^YJR159W MAE1^YKL029C MDH1^YKL085W MTD1^YKR080W PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C
• succinate
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C FBA1^YKL060C SDH2^YLL041C IDH1^YNL037C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• PDC6^YGR087C FBA1^YKL060C SDH2^YLL041C IDH2^YOR136W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH3^YKL141W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C FBA1^YKL060C SDH3^YKL141W IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W PDC6^YGR087C FBA1^YKL060C SDH3^YKL141W IDH2^YOR136W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W PDC6^YGR087C FBA1^YKL060C SDH1^YKL148C IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W PDC6^YGR087C FBA1^YKL060C SDH1^YKL148C IDH2^YOR136W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W PDC6^YGR087C FBA1^YKL060C SDH2^YLL041C IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• malate
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C PDC6^YGR087C SOR1^YJR159W MAE1^YKL029C MDH1^YKL085W MTD1^YKR080W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C PDC5^YLR134W LEU4^YNL104C
• succinate
• TPI1^YDR050C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• FBA1^YKL060C SDH2^YLL041C PDC1^YLR044C IDH1^YNL037C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• FBA1^YKL060C SDH2^YLL041C PDC1^YLR044C IDH2^YOR136W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• TPI1^YDR050C SDH4^YDR178W SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH4^YDR178W PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• TPI1^YDR050C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W FBA1^YKL060C SDH3^YKL141W PDC1^YLR044C IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W FBA1^YKL060C SDH3^YKL141W PDC1^YLR044C IDH2^YOR136W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W FBA1^YKL060C SDH1^YKL148C PDC1^YLR044C IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W FBA1^YKL060C SDH1^YKL148C PDC1^YLR044C IDH2^YOR136W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• SDH4^YDR178W FBA1^YKL060C SDH2^YLL041C PDC1^YLR044C IDH1^YNL037C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0725, FVA~min~R_EX_succ_e_ (pFBA)=0,1248]
• malate
• RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C SOR1^YJR159W MAE1^YKL029C MDH1^YKL085W MTD1^YKR080W PDC1^YLR044C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C AAT2^YLR027C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C SER3^YER081W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W AAT2^YLR027C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0771, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PRO1^YDR300C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0759, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MAE1^YKL029C PUT1^YLR142W MET2^YNL277W
• malate
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C TRX2^YGR209C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MDH1^YKL085W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0213, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MDH1^YKL085W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,3154, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C TAL1^YLR354C FBP1^YLR377C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• MAE1^YKL029C IDP2^YLR174W MET2^YNL277W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER33^YIL074C IDP2^YLR174W MET2^YNL277W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER3^YER081W IDP2^YLR174W MET2^YNL277W
• malate
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• IDP2^YLR174W ZWF1^YNL241C MET2^YNL277W
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W GAD1^YMR250W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]

---

• SER33^YIL074C MAE1^YKL029C TAL1^YLR354C
• malate
• SER3^YER081W NQM1^YGR043C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C PUT1^YLR142W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W MET17^YLR303W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C KGD1^YIL125W SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C
• malate
• SER3^YER081W MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W KGD1^YIL125W SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER33^YIL074C MAE1^YKL029C FBP1^YLR377C
• malate
• SER3^YER081W NQM1^YGR043C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C PUT1^YLR142W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C KGD1^YIL125W SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W MAE1^YKL029C TAL1^YLR354C
• malate
• NQM1^YGR043C SER33^YIL074C MDH1^YKL085W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C NQM1^YGR043C SER33^YIL074C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C PUT1^YLR142W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MET17^YLR303W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MET17^YLR303W FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C SER33^YIL074C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C SER33^YIL074C KGD1^YIL125W SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W NQM1^YGR043C MAE1^YKL029C
• malate
• SER33^YIL074C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• LSC2^YGR244C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER33^YIL074C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C SER33^YIL074C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W SER33^YIL074C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C SER33^YIL074C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER33^YIL074C KGD1^YIL125W SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W MAE1^YKL029C FBP1^YLR377C
• malate
• NQM1^YGR043C SER33^YIL074C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C NQM1^YGR043C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C PUT1^YLR142W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MET17^YLR303W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MET17^YLR303W TAL1^YLR354C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C SER33^YIL074C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C SER33^YIL074C KGD1^YIL125W SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• NQM1^YGR043C MET17^YLR303W TAL1^YLR354C
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• MET17^YLR303W TAL1^YLR354C FBP1^YLR377C
• succinate
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• ARO3^YDR035W KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• NQM1^YGR043C MET17^YLR303W FBP1^YLR377C
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• ARO3^YDR035W KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• ARO3^YDR035W KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• PGI1^YBR196C BAT1^YHR208W SER33^YIL074C
• succinate
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• KGD2^YDR148C PRO1^YDR300C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PRO1^YDR300C SER3^YER081W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• SER3^YER081W MAE1^YKL029C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]

---

• PGI1^YBR196C SER3^YER081W BAT1^YHR208W
• succinate
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• KGD2^YDR148C PRO1^YDR300C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• PRO1^YDR300C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3078, FVA~min~R_EX_fum_e_ (pFBA)=0,5308]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]
• SER33^YIL074C MAE1^YKL029C MET17^YLR303W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5337]

---

• SER33^YIL074C PDC1^YLR044C FBP1^YLR377C
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C SER33^YIL074C FBP1^YLR377C
• succinate
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER33^YIL074C PDC5^YLR134W FBP1^YLR377C
• succinate
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W PDC1^YLR044C FBP1^YLR377C
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• fumarate
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W PDC6^YGR087C FBP1^YLR377C
• succinate
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• fumarate
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W PDC5^YLR134W FBP1^YLR377C
• succinate
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1051, FVA~min~R_EX_succ_e_ (pFBA)=0,1812]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• fumarate
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• RPE1^YJL121C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C PDC5^YLR134W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C SOR1^YJR159W MAE1^YKL029C MTD1^YKR080W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C PDC6^YGR087C SOR1^YJR159W MAE1^YKL029C MTD1^YKR080W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C PDC1^YLR044C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C SOR1^YJR159W MAE1^YKL029C MTD1^YKR080W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• ACH1^YBL015W SER3^YER081W SER33^YIL074C
• succinate
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C ZWF1^YNL241C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• TPI1^YDR050C PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1099, FVA~min~R_EX_succ_e_ (pFBA)=0,1894]
• TPI1^YDR050C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4539, FVA~min~R_EX_succ_e_ (pFBA)=0,7828]
• fumarate
• GDH2^YDL215C MTD1^YKR080W PUT1^YLR142W IDH1^YNL037C ALD4^YOR374W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0654, FVA~min~R_EX_fum_e_ (pFBA)=0,1125]
• GDH2^YDL215C MTD1^YKR080W PUT1^YLR142W IDH2^YOR136W ALD4^YOR374W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0654, FVA~min~R_EX_fum_e_ (pFBA)=0,1125]
• ARO3^YDR035W GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0817, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]

---

• TPI1^YDR050C MDH1^YKL085W MET17^YLR303W
• succinate
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• malate
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W BAT1^YHR208W SER33^YIL074C AAT2^YLR027C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• BAT1^YHR208W SER33^YIL074C IDP2^YLR174W
• malate
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W ARO3^YDR035W SER3^YER081W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C SER3^YER081W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W RPE1^YJL121C MAE1^YKL029C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• SER3^YER081W DAK2^YFL053W MAE1^YKL029C ACP1^YKL192C DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GLT1^YDL171C GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER3^YER081W MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• SER3^YER081W BAT1^YHR208W IDP2^YLR174W
• malate
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W ARO3^YDR035W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GPD1^YDL022W GLT1^YDL171C SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GLT1^YDL171C ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4299, FVA~min~R_EX_fum_e_ (pFBA)=0,7415]
• GLT1^YDL171C PRO1^YDR300C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C MET17^YLR303W ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4368, FVA~min~R_EX_fum_e_ (pFBA)=0,7533]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• DAK2^YFL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]
• ARO3^YDR035W GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4369, FVA~min~R_EX_fum_e_ (pFBA)=0,7535]
• GPD1^YDL022W GLT1^YDL171C ARO3^YDR035W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C MET17^YLR303W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4351, FVA~min~R_EX_fum_e_ (pFBA)=0,7504]

---

• SER33^YIL074C TAL1^YLR354C MET2^YNL277W
• succinate
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• NQM1^YGR043C SER33^YIL074C MET2^YNL277W
• succinate
• SER3^YER081W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W TAL1^YLR354C MET2^YNL277W
• succinate
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER3^YER081W NQM1^YGR043C MET2^YNL277W
• succinate
• SER33^YIL074C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2648, FVA~min~R_EX_succ_e_ (pFBA)=0,4566]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• KGD2^YDR148C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• CHA1^YCL064C KGD2^YDR148C SER33^YIL074C MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• SER33^YIL074C MET17^YLR303W TAL1^YLR354C
• succinate
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• NQM1^YGR043C SER33^YIL074C MET17^YLR303W
• succinate
• SER3^YER081W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• SER3^YER081W LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER33^YIL074C MET17^YLR303W FBP1^YLR377C
• succinate
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH3^YKL141W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER3^YER081W NQM1^YGR043C SDH2^YLL041C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER3^YER081W MET17^YLR303W TAL1^YLR354C
• succinate
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER3^YER081W NQM1^YGR043C MET17^YLR303W
• succinate
• SER33^YIL074C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SER33^YIL074C SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W TAL1^YLR354C FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER3^YER081W MET17^YLR303W FBP1^YLR377C
• succinate
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH3^YKL141W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• NQM1^YGR043C SER33^YIL074C SDH2^YLL041C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0945, FVA~min~R_EX_succ_e_ (pFBA)=0,1628]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• SDH4^YDR178W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2642, FVA~min~R_EX_succ_e_ (pFBA)=0,4551]
• fumarate
• NQM1^YGR043C LSC2^YGR244C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C CAR2^YLR438W LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• MDH1^YKL085W PDC1^YLR044C LEU4^YNL104C
• succinate
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• malate
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C PDC6^YGR087C SOR1^YJR159W MAE1^YKL029C MTD1^YKR080W PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C MDH1^YKL085W LEU4^YNL104C
• succinate
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• malate
• RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C SOR1^YJR159W MAE1^YKL029C MTD1^YKR080W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MDH1^YKL085W PDC5^YLR134W LEU4^YNL104C
• succinate
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• malate
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,4510, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4513, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CYS3^YAL012W GDH2^YDL215C PDC6^YGR087C SOR1^YJR159W MAE1^YKL029C MTD1^YKR080W PDC1^YLR044C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4188, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• BAT1^YHR208W PDC1^YLR044C SHM2^YLR058C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• PDC6^YGR087C BAT1^YHR208W SHM2^YLR058C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• BAT1^YHR208W SHM2^YLR058C PDC5^YLR134W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• SER33^YIL074C MET17^YLR303W CAR2^YLR438W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH1^YKL148C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• fumarate
• TPI1^YDR050C SER3^YER081W SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• PGI1^YBR196C SER3^YER081W LSC2^YGR244C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER3^YER081W MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SHM2^YLR058C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• PGI1^YBR196C ARO3^YDR035W KGD2^YDR148C SER3^YER081W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C ARO3^YDR035W SER3^YER081W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER3^YER081W MET17^YLR303W CAR2^YLR438W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• fumarate
• TPI1^YDR050C SER33^YIL074C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• PGI1^YBR196C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• PGI1^YBR196C SER33^YIL074C MAE1^YKL029C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,3095, FVA~min~R_EX_fum_e_ (pFBA)=0,5338]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SHM2^YLR058C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• PGI1^YBR196C ARO3^YDR035W KGD2^YDR148C SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• PGI1^YBR196C ARO3^YDR035W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,3096, FVA~min~R_EX_fum_e_ (pFBA)=0,5340]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• ARO3^YDR035W TPI1^YDR050C SER33^YIL074C
• succinate
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• SER3^YER081W AGX1^YFL030W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• ARO3^YDR035W TPI1^YDR050C SER3^YER081W
• succinate
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• AGX1^YFL030W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C CAR2^YLR438W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,5042, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MDH1^YKL085W PDC1^YLR044C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• malate
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C MDH1^YKL085W MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• malate
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MDH1^YKL085W PDC5^YLR134W MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C IDH2^YOR136W ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C IDH1^YNL037C ALD6^YPL061W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1142, FVA~min~R_EX_succ_e_ (pFBA)=0,1969]
• malate
• PGI1^YBR196C AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MAE1^YKL029C TAL1^YLR354C LEU4^YNL104C
• malate
• ARO3^YDR035W PDA1^YER178W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• KGD2^YDR148C PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C NQM1^YGR043C BAT1^YHR208W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]

---

• NQM1^YGR043C MAE1^YKL029C LEU4^YNL104C
• malate
• ARO3^YDR035W PDA1^YER178W MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C BAT1^YHR208W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• BAT1^YHR208W KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• KGD2^YDR148C PRO1^YDR300C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C BAT1^YHR208W KGD1^YIL125W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]

---

• MAE1^YKL029C FBP1^YLR377C LEU4^YNL104C
• malate
• ARO3^YDR035W PDA1^YER178W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• KGD2^YDR148C PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C NQM1^YGR043C BAT1^YHR208W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]

---

• NQM1^YGR043C TAL1^YLR354C LEU4^YNL104C
• malate
• ARO3^YDR035W PDA1^YER178W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• KGD2^YDR148C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]

---

• TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C
• malate
• ARO3^YDR035W PDA1^YER178W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• KGD2^YDR148C PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C NQM1^YGR043C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C NQM1^YGR043C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]

---

• NQM1^YGR043C FBP1^YLR377C LEU4^YNL104C
• malate
• ARO3^YDR035W PDA1^YER178W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C ARO3^YDR035W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C BAT1^YHR208W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• KGD2^YDR148C PRO1^YDR300C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• PRO1^YDR300C LPD1^YFL018C BAT1^YHR208W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C BAT1^YHR208W KGD1^YIL125W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]

---

• ARO3^YDR035W MAE1^YKL029C TAL1^YLR354C
• malate
• PDA1^YER178W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C NQM1^YGR043C PUT1^YLR142W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• ARO3^YDR035W NQM1^YGR043C MAE1^YKL029C
• malate
• PDA1^YER178W MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C PUT1^YLR142W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD1^YIL125W PUT1^YLR142W MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• ARO3^YDR035W MAE1^YKL029C FBP1^YLR377C
• malate
• PDA1^YER178W NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C NQM1^YGR043C PUT1^YLR142W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• NQM1^YGR043C KGD1^YIL125W PUT1^YLR142W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• ARO3^YDR035W NQM1^YGR043C TAL1^YLR354C
• malate
• PDA1^YER178W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• ARO3^YDR035W TAL1^YLR354C FBP1^YLR377C
• malate
• PDA1^YER178W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• ARO3^YDR035W PUT1^YLR142W TAL1^YLR354C
• malate
• PDA1^YER178W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• ARO3^YDR035W NQM1^YGR043C FBP1^YLR377C
• malate
• PDA1^YER178W MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MAE1^YKL029C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C MAE1^YKL029C PUT1^YLR142W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD1^YIL125W MAE1^YKL029C PUT1^YLR142W MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• ARO3^YDR035W NQM1^YGR043C PUT1^YLR142W
• malate
• PDA1^YER178W MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD1^YIL125W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• ARO3^YDR035W PUT1^YLR142W FBP1^YLR377C
• malate
• PDA1^YER178W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDX1^YGR193C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0184, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2605, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2441, FVA~min~R_EX_fum_e_ (pFBA)=0,4211]
• KGD2^YDR148C NQM1^YGR043C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]

---

• SER33^YIL074C MDH1^YKL085W LEU4^YNL104C
• succinate
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• malate
• SER3^YER081W AGX1^YFL030W MAE1^YKL029C AAT2^YLR027C CAR2^YLR438W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W MDH1^YKL085W LEU4^YNL104C
• succinate
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• malate
• AGX1^YFL030W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C CAR2^YLR438W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C AAT2^YLR027C MET17^YLR303W
• malate
• ARO3^YDR035W TPI1^YDR050C SER3^YER081W AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W MDH1^YKL085W SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W AAT2^YLR027C MET17^YLR303W
• malate
• ARO3^YDR035W TPI1^YDR050C AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C AAT2^YLR027C MET17^YLR303W
• malate
• ARO3^YDR035W SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• SER3^YER081W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• MAE1^YKL029C TAL1^YLR354C MET2^YNL277W
• malate
• IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W AAT1^YKL106W MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2136, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W NQM1^YGR043C TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C PDX1^YGR193C TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W NQM1^YGR043C TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C PUT1^YLR142W FBP1^YLR377C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C PUT1^YLR142W FBP1^YLR377C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W SRY1^YKL218C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• NQM1^YGR043C MAE1^YKL029C MET2^YNL277W
• malate
• IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W AAT1^YKL106W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2136, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C FBA1^YKL060C MDH1^YKL085W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W BAT1^YHR208W SER33^YIL074C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• ACH1^YBL015W LSC2^YGR244C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W SER33^YIL074C SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W SER33^YIL074C KGD1^YIL125W SRY1^YKL218C TAL1^YLR354C FBP1^YLR377C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• ARO3^YDR035W PDC6^YGR087C PDC1^YLR044C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C SHM2^YLR058C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• ARO3^YDR035W PDC1^YLR044C PDC5^YLR134W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• ARO3^YDR035W PDC6^YGR087C PDC5^YLR134W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• GLT1^YDL171C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C DAK2^YFL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4184, FVA~min~R_EX_fum_e_ (pFBA)=0,7216]
• DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GLT1^YDL171C GLY1^YEL046C DAK2^YFL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4202, FVA~min~R_EX_fum_e_ (pFBA)=0,7247]
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• ARO3^YDR035W TPI1^YDR050C MET17^YLR303W
• succinate
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• SER3^YER081W AGX1^YFL030W IRC7^YFR055W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,5149, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PGI1^YBR196C PDC1^YLR044C MET2^YNL277W
• succinate
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• malate
• AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PGI1^YBR196C PDC6^YGR087C MET2^YNL277W
• succinate
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• malate
• AGX1^YFL030W IRC7^YFR055W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PGI1^YBR196C PDC5^YLR134W MET2^YNL277W
• succinate
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• malate
• AGX1^YFL030W IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,3146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C CAR2^YLR438W LEU4^YNL104C
• malate
• SER3^YER081W AGX1^YFL030W MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER3^YER081W CAR2^YLR438W LEU4^YNL104C
• malate
• AGX1^YFL030W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT2^YLR027C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,4077, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SHM2^YLR058C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER33^YIL074C MDH1^YKL085W PDC1^YLR044C
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C SER33^YIL074C MDH1^YKL085W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• SER3^YER081W MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C MDH1^YKL085W PDC5^YLR134W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W MDH1^YKL085W PDC1^YLR044C
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W PDC6^YGR087C MDH1^YKL085W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W MDH1^YKL085W PDC5^YLR134W
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C AAT2^YLR027C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C PDC1^YLR044C LEU4^YNL104C
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C SER33^YIL074C LEU4^YNL104C
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C PDC5^YLR134W LEU4^YNL104C
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W PDC1^YLR044C LEU4^YNL104C
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W PDC6^YGR087C LEU4^YNL104C
• succinate
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W PDC5^YLR134W LEU4^YNL104C
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,4707, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• ACH1^YBL015W NQM1^YGR043C TAL1^YLR354C
• succinate
• IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• fumarate
• LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• MAE1^YKL029C PUT1^YLR142W FBP1^YLR377C MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• ACH1^YBL015W TAL1^YLR354C FBP1^YLR377C
• succinate
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• fumarate
• NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• NQM1^YGR043C MAE1^YKL029C PUT1^YLR142W MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• ACH1^YBL015W NQM1^YGR043C FBP1^YLR377C
• succinate
• IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• IDP1^YDL066W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2552, FVA~min~R_EX_succ_e_ (pFBA)=0,4400]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2546, FVA~min~R_EX_succ_e_ (pFBA)=0,4390]
• fumarate
• LSC2^YGR244C MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C MET2^YNL277W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• MAE1^YKL029C PUT1^YLR142W TAL1^YLR354C MET2^YNL277W LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C
• malate
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C MAE1^YKL029C TAL1^YLR354C
• malate
• IRC7^YFR055W NQM1^YGR043C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C
• malate
• IRC7^YFR055W MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C MAE1^YKL029C FBP1^YLR377C
• malate
• IRC7^YFR055W NQM1^YGR043C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• NQM1^YGR043C PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C MAE1^YKL029C PDC5^YLR134W
• malate
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDC6^YGR087C FBA1^YKL060C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2146, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W PDC1^YLR044C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• BAT1^YHR208W SER33^YIL074C FBP1^YLR377C
• succinate
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER3^YER081W BAT1^YHR208W FBP1^YLR377C
• succinate
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• fumarate
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• BAT1^YHR208W FBP1^YLR377C MET2^YNL277W
• succinate
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• GDH3^YAL062W IPP1^YBR011C PGI1^YBR196C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,3402, FVA~min~R_EX_succ_e_ (pFBA)=0,5867]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• NQM1^YGR043C BAT1^YHR208W TAL1^YLR354C
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• PRO1^YDR300C PFK1^YGR240C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2021, FVA~min~R_EX_fum_e_ (pFBA)=0,3486]
• PRO1^YDR300C MAE1^YKL029C PFK2^YMR205C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,2021, FVA~min~R_EX_fum_e_ (pFBA)=0,3486]
• KGD2^YDR148C MAE1^YKL029C FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2452, FVA~min~R_EX_fum_e_ (pFBA)=0,4228]
• KGD2^YDR148C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C YML082W^YML082W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2444, FVA~min~R_EX_fum_e_ (pFBA)=0,4215]
• KGD2^YDR148C PRO1^YDR300C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• KGD2^YDR148C SER3^YER081W SER33^YIL074C MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• PRO1^YDR300C LPD1^YFL018C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0208, FVA~min~R_EX_fum_e_ (pFBA)=0,0356]
• PRO1^YDR300C KGD1^YIL125W MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2454, FVA~min~R_EX_fum_e_ (pFBA)=0,4232]
• SER3^YER081W LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W SER33^YIL074C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• PDC1^YLR044C FBP1^YLR377C MET2^YNL277W
• succinate
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C FBP1^YLR377C MET2^YNL277W
• succinate
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• malate
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC5^YLR134W FBP1^YLR377C MET2^YNL277W
• succinate
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• GDH3^YAL062W IDP1^YDL066W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MAE1^YKL029C FBP1^YLR377C MET2^YNL277W
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C KGD1^YIL125W TAL1^YLR354C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2629, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C PUT1^YLR142W TAL1^YLR354C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C PUT1^YLR142W TAL1^YLR354C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• CHA1^YCL064C KGD2^YDR148C SER3^YER081W NQM1^YGR043C SER33^YIL074C SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]
• CHA1^YCL064C SER3^YER081W NQM1^YGR043C SER33^YIL074C KGD1^YIL125W SRY1^YKL218C TAL1^YLR354C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2630, FVA~min~R_EX_fum_e_ (pFBA)=0,4535]

---

• BAT1^YHR208W SER33^YIL074C SHM2^YLR058C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• GLY1^YEL046C SER3^YER081W MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• TPI1^YDR050C SER3^YER081W MDH1^YKL085W AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W BAT1^YHR208W SHM2^YLR058C
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• GLY1^YEL046C SER33^YIL074C MAE1^YKL029C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• TPI1^YDR050C SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER33^YIL074C LEU4^YNL104C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• malate
• SER3^YER081W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W LEU4^YNL104C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• malate
• PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC1^YLR044C LEU4^YNL104C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• malate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C LEU4^YNL104C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• malate
• SER3^YER081W SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC5^YLR134W LEU4^YNL104C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• malate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C RPE1^YJL121C MAE1^YKL029C MDH1^YKL085W AAT1^YKL106W PDC1^YLR044C PUT1^YLR142W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,4686, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C FBP1^YLR377C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• TPI1^YDR050C SER33^YIL074C SHM2^YLR058C
• succinate
• SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER3^YER081W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER3^YER081W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER3^YER081W SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER3^YER081W SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER3^YER081W SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER3^YER081W SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER3^YER081W SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER3^YER081W SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• IPP1^YBR011C SER3^YER081W SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• fumarate
• SER3^YER081W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• SER3^YER081W MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER3^YER081W MET17^YLR303W CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• SER3^YER081W BAT1^YHR208W MDH1^YKL085W AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C SER3^YER081W SHM2^YLR058C
• succinate
• SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=5,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SER33^YIL074C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• IPP1^YBR011C SER33^YIL074C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1053, FVA~min~R_EX_succ_e_ (pFBA)=0,1808]
• fumarate
• SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• SER33^YIL074C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER33^YIL074C MET17^YLR303W CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• BAT1^YHR208W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• PUT1^YLR142W TAL1^YLR354C MET2^YNL277W
• malate
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C PDX1^YGR193C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W NQM1^YGR043C TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C PDX1^YGR193C TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W NQM1^YGR043C TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C PDX1^YGR193C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C FBP1^YLR377C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• NQM1^YGR043C PUT1^YLR142W MET2^YNL277W
• malate
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W TRX2^YGR209C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W PDA1^YER178W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W PDX1^YGR193C MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W LPD1^YFL018C IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0128, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C TAL1^YLR354C LAT1^YNL071W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• PDB1^YBR221C TSA2^YDR453C ADK2^YER170W IRC7^YFR055W MAE1^YKL029C FBA1^YKL060C MDH1^YKL085W TRX1^YLR043C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2162, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ACH1^YBL015W LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• SER33^YIL074C AAT2^YLR027C PDC1^YLR044C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C SER33^YIL074C AAT2^YLR027C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C AAT2^YLR027C PDC5^YLR134W
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W AAT2^YLR027C PDC1^YLR044C
• succinate
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W PDC6^YGR087C AAT2^YLR027C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W AAT2^YLR027C PDC5^YLR134W
• succinate
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MDH1^YKL085W AAT2^YLR027C PDC1^YLR044C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C MDH1^YKL085W AAT2^YLR027C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MDH1^YKL085W AAT2^YLR027C PDC5^YLR134W
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C SRY1^YKL218C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C AAT2^YLR027C PDC1^YLR044C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• AAT2^YLR027C PDC1^YLR044C PDC5^YLR134W
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SHM2^YLR058C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C AAT2^YLR027C PDC5^YLR134W
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4488, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IDP1^YDL066W SER3^YER081W AGX1^YFL030W DAK2^YFL053W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,3861, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• CHA1^YCL064C SER3^YER081W AGX1^YFL030W DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W SRY1^YKL218C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=18,0000, CYIELD (pFBA)=0,3914, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER33^YIL074C MDH1^YKL085W FBP1^YLR377C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• malate
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• SER3^YER081W MDH1^YKL085W FBP1^YLR377C
• succinate
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• malate
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,2746, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• AAT2^YLR027C PDC1^YLR044C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C AAT2^YLR027C MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• AAT2^YLR027C PDC5^YLR134W MET2^YNL277W
• succinate
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• malate
• GPD1^YDL022W SER3^YER081W PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C IDP2^YLR174W GAD1^YMR250W ZWF1^YNL241C MDH2^YOL126C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4845, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C PDC1^YLR044C CAR2^YLR438W
• succinate
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C SER3^YER081W SER33^YIL074C SRY1^YKL218C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC1^YLR044C PDC5^YLR134W CAR2^YLR438W
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SRY1^YKL218C SDH2^YLL041C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C PDC5^YLR134W CAR2^YLR438W
• succinate
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C SER3^YER081W SER33^YIL074C SRY1^YKL218C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4201, FVA~min~R_EX_fum_e_ (pFBA)=0,7245]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PUT1^YLR142W FBP1^YLR377C MET2^YNL277W
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• ACH1^YBL015W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]
• ACH1^YBL015W NQM1^YGR043C MAE1^YKL029C TAL1^YLR354C LSC1^YOR142W ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2445, FVA~min~R_EX_fum_e_ (pFBA)=0,4216]

---

• TPI1^YDR050C SHM2^YLR058C MET17^YLR303W
• succinate
• SER3^YER081W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SDH4^YDR178W SER3^YER081W SER33^YIL074C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C AAT1^YKL106W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C SDH3^YKL141W SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH4^YLR164W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH3^YMR118C [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1071, FVA~min~R_EX_succ_e_ (pFBA)=0,1840]
• SER3^YER081W SER33^YIL074C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1077, FVA~min~R_EX_succ_e_ (pFBA)=0,1857]
• GDH3^YAL062W SER3^YER081W SER33^YIL074C SDH2^YLL041C GDH1^YOR375C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2010]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1111, FVA~min~R_EX_succ_e_ (pFBA)=0,1908]
• fumarate
• SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=6,0000, CYIELD (pFBA)=0,1154, FVA~min~R_EX_fum_e_ (pFBA)=0,1989]
• SER3^YER081W SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C CAR2^YLR438W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]
• SER3^YER081W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• ARO3^YDR035W SER33^YIL074C PDC1^YLR044C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• ARO3^YDR035W PDC6^YGR087C SER33^YIL074C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• ARO3^YDR035W SER33^YIL074C PDC5^YLR134W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W GLY1^YEL046C SER3^YER081W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C SER3^YER081W DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• ARO3^YDR035W SER3^YER081W PDC1^YLR044C
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• ARO3^YDR035W SER3^YER081W PDC6^YGR087C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• ARO3^YDR035W SER3^YER081W PDC5^YLR134W
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GPD1^YDL022W GLY1^YEL046C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=16,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLT1^YDL171C GLY1^YEL046C GPP2^YER062C PDC6^YGR087C BAT1^YHR208W GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7508]
• GLY1^YEL046C DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W NDI1^YML120C ZWF1^YNL241C PRO2^YOR323C FUM1^YPL262W [#knockouts (pFBA)=17,0000, CYIELD (pFBA)=0,4336, FVA~min~R_EX_fum_e_ (pFBA)=0,7478]

---

• SER33^YIL074C PDC1^YLR044C CAR2^YLR438W
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SRY1^YKL218C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• PDC6^YGR087C SER33^YIL074C CAR2^YLR438W
• succinate
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C SER3^YER081W SRY1^YKL218C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLY1^YEL046C GPP2^YER062C SER3^YER081W GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• SER33^YIL074C PDC5^YLR134W CAR2^YLR438W
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SRY1^YKL218C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLY1^YEL046C GPP2^YER062C SER3^YER081W PDC6^YGR087C GPP1^YIL053W MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• SER3^YER081W PDC1^YLR044C CAR2^YLR438W
• succinate
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SRY1^YKL218C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• SER3^YER081W PDC6^YGR087C CAR2^YLR438W
• succinate
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C SER33^YIL074C SRY1^YKL218C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLY1^YEL046C GPP2^YER062C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• SER3^YER081W PDC5^YLR134W CAR2^YLR438W
• succinate
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• IPP1^YBR011C CHA1^YCL064C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SRY1^YKL218C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0971, FVA~min~R_EX_succ_e_ (pFBA)=0,1673]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• GLY1^YEL046C GPP2^YER062C PDC6^YGR087C GPP1^YIL053W SER33^YIL074C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,4353, FVA~min~R_EX_fum_e_ (pFBA)=0,7507]

---

• BAT1^YHR208W PDC1^YLR044C MET17^YLR303W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• PDC6^YGR087C BAT1^YHR208W MET17^YLR303W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• BAT1^YHR208W PDC5^YLR134W MET17^YLR303W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• GPD1^YDL022W GLT1^YDL171C GLY1^YEL046C PDC6^YGR087C MAE1^YKL029C ACP1^YKL192C PDC1^YLR044C IDP2^YLR174W NDI1^YML120C ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,4203, FVA~min~R_EX_fum_e_ (pFBA)=0,7249]

---

• ARO3^YDR035W PDC1^YLR044C SHM2^YLR058C
• succinate
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W MET17^YLR303W SHH3^YMR118C LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• fumarate
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]

---

• ARO3^YDR035W PDC6^YGR087C SHM2^YLR058C
• succinate
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• fumarate
• DAK2^YFL053W RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]

---

• ARO3^YDR035W SHM2^YLR058C PDC5^YLR134W
• succinate
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C MET17^YLR303W SHH3^YMR118C LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C MET17^YLR303W SHH3^YMR118C LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• GDH3^YAL062W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHH4^YLR164W MET17^YLR303W LEU4^YNL104C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• fumarate
• DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C MAE1^YKL029C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]

---

• BAT1^YHR208W SER33^YIL074C TAL1^YLR354C
• succinate
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• NQM1^YGR043C BAT1^YHR208W SER33^YIL074C
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER3^YER081W MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER3^YER081W BAT1^YHR208W TAL1^YLR354C
• succinate
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MET17^YLR303W FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER3^YER081W NQM1^YGR043C BAT1^YHR208W
• succinate
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C MET2^YNL277W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]
• SER33^YIL074C MAE1^YKL029C MET17^YLR303W TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2628, FVA~min~R_EX_fum_e_ (pFBA)=0,4533]

---

• SER33^YIL074C PDC1^YLR044C TAL1^YLR354C
• succinate
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C SER33^YIL074C PDC1^YLR044C
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• PDC6^YGR087C SER33^YIL074C TAL1^YLR354C
• succinate
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C
• succinate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER3^YER081W MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER33^YIL074C PDC5^YLR134W TAL1^YLR354C
• succinate
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• NQM1^YGR043C SER33^YIL074C PDC5^YLR134W
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C BAT1^YHR208W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER3^YER081W PDC6^YGR087C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W PDC1^YLR044C TAL1^YLR354C
• succinate
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W NQM1^YGR043C PDC1^YLR044C
• succinate
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W PDC6^YGR087C TAL1^YLR354C
• succinate
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W NQM1^YGR043C PDC6^YGR087C
• succinate
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W PDC5^YLR134W TAL1^YLR354C
• succinate
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W NQM1^YGR043C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• SER3^YER081W NQM1^YGR043C PDC5^YLR134W
• succinate
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C BAT1^YHR208W SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]
• PDC6^YGR087C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,2613, FVA~min~R_EX_fum_e_ (pFBA)=0,4506]

---

• MDH1^YKL085W PDC1^YLR044C FBP1^YLR377C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• PDC6^YGR087C MDH1^YKL085W FBP1^YLR377C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• malate
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C MAE1^YKL029C PDC1^YLR044C PDC5^YLR134W PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MDH1^YKL085W PDC5^YLR134W FBP1^YLR377C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W AAT2^YLR027C PDC1^YLR044C SHM2^YLR058C SHH4^YLR164W GDH1^YOR375C [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• malate
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C TAL1^YLR354C MDH2^YOL126C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,2593, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• IRC7^YFR055W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C PDC1^YLR044C PUT1^YLR142W TAL1^YLR354C LEU4^YNL104C MET2^YNL277W MDH2^YOL126C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,2640, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]

---

• MAE1^YKL029C PDC1^YLR044C SHM2^YLR058C
• succinate
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• fumarate
• IDP1^YDL066W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W RPE1^YJL121C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W RPE1^YJL121C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• PDC6^YGR087C MAE1^YKL029C SHM2^YLR058C
• succinate
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• fumarate
• IDP1^YDL066W GPP2^YER062C GPP1^YIL053W RPE1^YJL121C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W RPE1^YJL121C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W BAT1^YHR208W RPE1^YJL121C PDC1^YLR044C PDC5^YLR134W IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• MAE1^YKL029C SHM2^YLR058C PDC5^YLR134W
• succinate
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHH3^YMR118C [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• SDH4^YDR178W PRO1^YDR300C GLY1^YEL046C PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHH4^YLR164W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0240, FVA~min~R_EX_succ_e_ (pFBA)=0,0411]
• fumarate
• IDP1^YDL066W GPP2^YER062C PDC6^YGR087C GPP1^YIL053W RPE1^YJL121C PDC1^YLR044C IDP2^YLR174W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3677, FVA~min~R_EX_fum_e_ (pFBA)=0,6338]
• ARO3^YDR035W DAK2^YFL053W PDC6^YGR087C RPE1^YJL121C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3609, FVA~min~R_EX_fum_e_ (pFBA)=0,6223]
• DAK2^YFL053W PDC6^YGR087C BAT1^YHR208W RPE1^YJL121C PDC1^YLR044C IDP2^YLR174W DAK1^YML070W ZWF1^YNL241C FUM1^YPL262W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,3608, FVA~min~R_EX_fum_e_ (pFBA)=0,6222]

---

• TPI1^YDR050C MET17^YLR303W CAR2^YLR438W
• succinate
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SDH3^YKL141W SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SDH1^YKL148C SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SDH2^YLL041C SHH3^YMR118C ALD6^YPL061W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C YJL045W^YJL045W SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH1^YKL148C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SDH2^YLL041C ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W SER33^YIL074C SDH3^YKL141W SHH4^YLR164W ALD6^YPL061W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0970, FVA~min~R_EX_succ_e_ (pFBA)=0,1671]
• fumarate
• SER3^YER081W SER33^YIL074C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SHM2^YLR058C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER33^YIL074C PUT1^YLR142W TAL1^YLR354C
• malate
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W NQM1^YGR043C LSC2^YGR244C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W NQM1^YGR043C MAE1^YKL029C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]

---

• NQM1^YGR043C SER33^YIL074C PUT1^YLR142W
• malate
• SER3^YER081W PDC6^YGR087C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER3^YER081W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W LPD1^YFL018C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• SER3^YER081W LSC2^YGR244C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER3^YER081W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]

---

• SER3^YER081W PUT1^YLR142W TAL1^YLR354C
• malate
• NQM1^YGR043C PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• NQM1^YGR043C LSC2^YGR244C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C KGD1^YIL125W MAE1^YKL029C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• NQM1^YGR043C SER33^YIL074C MAE1^YKL029C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]

---

• SER3^YER081W NQM1^YGR043C PUT1^YLR142W
• malate
• PDC6^YGR087C SER33^YIL074C MAE1^YKL029C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C LEU4^YNL104C MDH2^YOL126C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0248, FVA~min~R_EX_mal_L_e_ (pFBA)=0,0000]
• fumarate
• KGD2^YDR148C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• LPD1^YFL018C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0389, FVA~min~R_EX_fum_e_ (pFBA)=0,0670]
• LSC2^YGR244C SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C KGD1^YIL125W MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]
• SER33^YIL074C MAE1^YKL029C TAL1^YLR354C FBP1^YLR377C LSC1^YOR142W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,2611, FVA~min~R_EX_fum_e_ (pFBA)=0,4503]

---

• TPI1^YDR050C MET17^YLR303W LEU4^YNL104C
• succinate
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• SDH4^YDR178W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,0729, FVA~min~R_EX_succ_e_ (pFBA)=0,1256]
• fumarate
• IPP1^YBR011C SER3^YER081W SER33^YIL074C SHM2^YLR058C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER33^YIL074C SHM2^YLR058C CAR2^YLR438W
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• TPI1^YDR050C SER3^YER081W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W MET17^YLR303W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER3^YER081W SHM2^YLR058C CAR2^YLR438W
• succinate
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• TPI1^YDR050C SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C MET17^YLR303W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SHM2^YLR058C MET17^YLR303W CAR2^YLR438W
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• TPI1^YDR050C SER3^YER081W SER33^YIL074C FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• TPI1^YDR050C SHM2^YLR058C CAR2^YLR438W
• succinate
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• GDH3^YAL062W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1177, FVA~min~R_EX_succ_e_ (pFBA)=0,2028]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1078, FVA~min~R_EX_succ_e_ (pFBA)=0,1858]
• fumarate
• SER3^YER081W SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=7,0000, CYIELD (pFBA)=0,1155, FVA~min~R_EX_fum_e_ (pFBA)=0,1990]
• IPP1^YBR011C SER3^YER081W SER33^YIL074C MET17^YLR303W LEU4^YNL104C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER33^YIL074C MDH1^YKL085W SHM2^YLR058C
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W MDH1^YKL085W SHM2^YLR058C
• succinate
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C MDH1^YKL085W SHM2^YLR058C
• succinate
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• SER3^YER081W BAT1^YHR208W SER33^YIL074C AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C SER33^YIL074C LEU4^YNL104C
• succinate
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• IPP1^YBR011C SER3^YER081W SHM2^YLR058C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• TPI1^YDR050C SER3^YER081W LEU4^YNL104C
• succinate
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W ARO3^YDR035W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• ACH1^YBL015W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0979, FVA~min~R_EX_succ_e_ (pFBA)=0,1687]
• IPP1^YBR011C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• IPP1^YBR011C SER33^YIL074C SHM2^YLR058C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• BAT1^YHR208W SHM2^YLR058C MET17^YLR303W
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• GLY1^YEL046C SER3^YER081W SER33^YIL074C MAE1^YKL029C FUM1^YPL262W [#knockouts (pFBA)=8,0000, CYIELD (pFBA)=0,1015, FVA~min~R_EX_fum_e_ (pFBA)=0,1749]
• TPI1^YDR050C SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C BAT1^YHR208W SHM2^YLR058C
• succinate
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SDH4^YDR178W SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• SER3^YER081W NQM1^YGR043C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W TAL1^YLR354C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1252, FVA~min~R_EX_succ_e_ (pFBA)=0,2159]
• fumarate
• SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER33^YIL074C SHM2^YLR058C LEU4^YNL104C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• ACH1^YBL015W IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W IDH1^YNL037C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2016]
• ACH1^YBL015W IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W IDH2^YOR136W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2016]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• fumarate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER3^YER081W SHM2^YLR058C LEU4^YNL104C
• succinate
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• GDH3^YAL062W ACH1^YBL015W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• ACH1^YBL015W IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W IDH1^YNL037C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2016]
• ACH1^YBL015W IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W IDH2^YOR136W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2016]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• fumarate
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• TPI1^YDR050C SHM2^YLR058C LEU4^YNL104C
• succinate
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1236, FVA~min~R_EX_succ_e_ (pFBA)=0,2131]
• GDH3^YAL062W ARO3^YDR035W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• ACH1^YBL015W IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W IDH1^YNL037C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2016]
• ACH1^YBL015W IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W IDH2^YOR136W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2016]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• fumarate
• IPP1^YBR011C SER3^YER081W SER33^YIL074C MET17^YLR303W CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER33^YIL074C MET17^YLR303W LEU4^YNL104C
• succinate
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• fumarate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SHM2^YLR058C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SER3^YER081W MET17^YLR303W LEU4^YNL104C
• succinate
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• ACH1^YBL015W ARO3^YDR035W TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• fumarate
• IPP1^YBR011C TPI1^YDR050C SER33^YIL074C SHM2^YLR058C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• SHM2^YLR058C MET17^YLR303W LEU4^YNL104C
• succinate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• GDH3^YAL062W ARO3^YDR035W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1187, FVA~min~R_EX_succ_e_ (pFBA)=0,2046]
• ACH1^YBL015W IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W IDH1^YNL037C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2016]
• ACH1^YBL015W IPP1^YBR011C TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W IDH2^YOR136W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1170, FVA~min~R_EX_succ_e_ (pFBA)=0,2016]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• IPP1^YBR011C TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1130, FVA~min~R_EX_succ_e_ (pFBA)=0,1947]
• fumarate
• IPP1^YBR011C TPI1^YDR050C SER3^YER081W SER33^YIL074C CAR2^YLR438W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1202, FVA~min~R_EX_fum_e_ (pFBA)=0,2071]

---

• TPI1^YDR050C BAT1^YHR208W MET17^YLR303W
• succinate
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• IPP1^YBR011C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C SHM2^YLR058C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1117, FVA~min~R_EX_succ_e_ (pFBA)=0,1926]
• fumarate
• SER3^YER081W SER33^YIL074C MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER33^YIL074C AAT2^YLR027C SHM2^YLR058C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• fumarate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W MDH1^YKL085W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• SER3^YER081W AAT2^YLR027C SHM2^YLR058C
• succinate
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• fumarate
• TPI1^YDR050C BAT1^YHR208W SER33^YIL074C MDH1^YKL085W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• MDH1^YKL085W AAT2^YLR027C SHM2^YLR058C
• succinate
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W FBP1^YLR377C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• GDH3^YAL062W ACH1^YBL015W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W FBP1^YLR377C SHH3^YMR118C GDH1^YOR375C [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1232, FVA~min~R_EX_succ_e_ (pFBA)=0,2123]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W TPI1^YDR050C ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• fumarate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SER33^YIL074C MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• MDH1^YKL085W SHM2^YLR058C MET17^YLR303W
• succinate
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C LSC2^YGR244C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• ACH1^YBL015W TPI1^YDR050C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W LSC1^YOR142W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1136, FVA~min~R_EX_succ_e_ (pFBA)=0,1958]
• fumarate
• TPI1^YDR050C SER3^YER081W BAT1^YHR208W SER33^YIL074C AAT2^YLR027C FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• TPI1^YDR050C AAT2^YLR027C SHM2^YLR058C
• succinate
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH3^YMR118C MET2^YNL277W [#knockouts (pFBA)=14,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W MDH1^YKL085W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• ACH1^YBL015W ALT2^YDR111C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SER33^YIL074C MDH1^YKL085W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET2^YNL277W [#knockouts (pFBA)=15,0000, CYIELD (pFBA)=0,1174, FVA~min~R_EX_succ_e_ (pFBA)=0,2024]
• fumarate
• SER3^YER081W BAT1^YHR208W SER33^YIL074C MDH1^YKL085W MET17^YLR303W FUM1^YPL262W [#knockouts (pFBA)=9,0000, CYIELD (pFBA)=0,1205, FVA~min~R_EX_fum_e_ (pFBA)=0,2077]

---

• ACH1^YBL015W ARO3^YDR035W SER33^YIL074C
• succinate
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SER3^YER081W PDC6^YGR087C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W SER3^YER081W PDC6^YGR087C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GLY1^YEL046C SER3^YER081W BAT1^YHR208W MAE1^YKL029C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0817, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]

---

• ACH1^YBL015W ARO3^YDR035W SER3^YER081W
• succinate
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=11,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH1^YKL148C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C PDC6^YGR087C SER33^YIL074C SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W SHH3^YMR118C LEU4^YNL104C [#knockouts (pFBA)=12,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C YJL045W^YJL045W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH1^YKL148C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W SDH2^YLL041C PDC1^YLR044C PDC5^YLR134W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• TPI1^YDR050C SDH4^YDR178W PDC6^YGR087C SER33^YIL074C SDH3^YKL141W PDC1^YLR044C PDC5^YLR134W SHH4^YLR164W MET17^YLR303W LEU4^YNL104C [#knockouts (pFBA)=13,0000, CYIELD (pFBA)=0,0981, FVA~min~R_EX_succ_e_ (pFBA)=0,1690]
• fumarate
• GLY1^YEL046C BAT1^YHR208W SER33^YIL074C MAE1^YKL029C ALD4^YOR374W ALD6^YPL061W FUM1^YPL262W [#knockouts (pFBA)=10,0000, CYIELD (pFBA)=0,0817, FVA~min~R_EX_fum_e_ (pFBA)=0,1407]